TABLE 2

AUC_0–48h, AUC_inf, and T_1/2 of icenticaftor and its metabolites in plasma based on metabolite pattern analysis

Peak^a	Compound/ metabolite	AUC_0–48h (nmol*h/L)	Percentage AUC_0–48h	AUC_inf (nmol*h/L)	Percentage AUC_inf	T_1/2 (h)
M5	O-demethylation, glucuronidation	12800	10.7	13800	10.7	12.1
M8	N-glucuronidation	42200	35.3	44100	33.9	11.2
M9	O-glucuronidation	17300	14.5	18100	13.9	11.6
M10	C-hydroxylation	2310	1.93	2840	2.19	–
M14	O-demethylation	1790	1.50	2000	1.54	16.8
M17	N-dealkylation	3630	3.04	3840	2.96	10.7
Icenticaftor	Parent drug	22100	18.5	22700^b	17.5	11.2
	Sum of minor identified metabolites (each ≤1%)	7930	6.63	–	–	–
	Sum of unknown trace metabolites (each ≤0.30%)	515	0.430	–	–	–
	Lost during sample processing and HPLC	8870	7.42	–	–	–
Total ¹⁴C (total of radiolabeled components)		120000	100	130000	100	14.2

–, not calculated; AUC_0–48h, area under the concentration-time curve from time zero to 48 hours.
↵^aListed in order of elution.
↵^b8200 ng*h/ml.