Research ArticlesNew Method for Calculating the Intrinsic Absorption Rate of Drugs
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Cited by (433)
Accelerated and Biopredictive In Vitro Release Testing Strategy for Single Agent and Combination Long-Acting Injectables
2024, Journal of Pharmaceutical SciencesFrom in vitro to in vivo: A comprehensive guide to IVIVC development for long-acting therapeutics
2023, Advanced Drug Delivery ReviewsNovel extended IVIVC combined with DoE to predict pharmacokinetics from formulation compositions
2022, Journal of Controlled ReleaseCitation Excerpt :The advantages of the population PK model to estimate the in vivo dissolution kinetics from the in vivo plasma concentration-time profile have been well demonstrated [8,10,11,16]. While conventional IVIVC methods only account for the net effect of in vivo dissolution and absorption [23,24], population PK-based IVIVC describes dissolution and absorption separately and physiological factors affecting each process could be incorporated. By using population pharmacokinetic modeling, therefore, IVIVC could be established for a wide variety of drugs including biopharmaceutical classification system (BCS) class III or IV drugs, which was not possible otherwise [8,10,11,16].
The science of pharmacokinetics: An overview and applications
2020, Remington: The Science and Practice of PharmacyNovel extended in vitro-in vivo correlation model for the development of extended-release formulations for baclofen: From formulation composition to in vivo pharmacokinetics
2019, International Journal of PharmaceuticsCitation Excerpt :Various mathematical approaches have been used to estimate the in vivo dissolution profiles from the plasma concentration-time data. Conventional IVIVC approaches utilize mathematical methods such as the Wagner and Nelson (1963) and the Loo and Riegelman (1968) methods, or use numerical deconvolution (Cutler, 1978). While these conventional approaches are applicable only to highly permeable drugs such as the class I or class II drugs of the Biopharmaceutics Classification System (BCS) (Park, 2013, 2014), recent population pharmacokinetic modeling approaches can extend their application to drugs with complex physiological absorption processes (Abuhelwa et al., 2016; Kim et al., 2017a).
In vitro–in vivo correlation of microsphere formulations: recent advances and challenges
2024, Journal of Pharmaceutical Investigation
Presented to the Basic Pharmaceutics Section, APhA Academy of Pharmaceutical Sciences, Las Vegas meeting, April 1967.
This research was supported in part by a grant-in-aid from the research funds of the Academic Senate, San Francisco Division, University of California.