Research ArticlePharmacokinetics of Acetylsalicylic Acid and Salicylic Acid After Intravenous Administration in Man
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2020, European Journal of PharmacologyCitation Excerpt :According to the results from the studies performed in healthy volunteers, the peak plasma concentration after administration of soluble aspirin (600 mg per day) was higher than that of other orally administered formulations (13.82 μg/ml versus 5.51 μg/ml with 650 mg plain aspirin per day orally), as well as the half-life was twice shorter (16 min versus 32 min, respectively) (Muir et al., 1997). However, such a study did not include intravenous aspirin, which has been shown to have the half-time of 2.8 min and 15 min in the initial distribution and the elimination phase, respectively (Rowland and Rielgelma, 1968); it has been indicated that intravenous aspirin is rapidly converted to salicylic acid by hydrolysis and presystemic COX-2 acetylation (Nagelschmitz et al., 2014), which may contribute to its antiplatelet and other pharmacologic effects (Giménez-Bastida et al., 2019). Anyway, aspirin at doses of 1 g per day (or higher) administered intravenously or orally is not recommended as atherothrombotic prophylaxis (FitzGerald et al., 1983).
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2017, Applied Animal Behaviour ScienceCitation Excerpt :However, the non-detection of ASA from whole body homogenate does not necessarily mean that no uptake had occurred. In human trials the drug has been shown to be hydrolyze quickly after intravenous injection, with a half-life of less than 3 min (Rowland and Riegelman, 1968). In the present study ASA (rather than salicylic acid resulting from hydrolysis) was used as reference compound for mass spectrometry and there may simply not have been sufficient pre-hydrolysis ASA in the body homogenate.
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Supported in part by funds from the University of California, Academic Senate Research Committee, and Sterling-Winthrop Laboratories, Rensselaer, N. Y.