Research ArticlesDisposition and Absolute Bioavailability of Furosemide in Healthy Males
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Extent and rate of oral drug absorption in minipigs: Comparison with mice, rats and humans
2020, Journal of Drug Delivery Science and TechnologyCitation Excerpt :CLb = CLp/RBCLh = CLb • (1 – fe)Fh = 1 – CLh/QhFa • Fg = BA/Fh All observed human values after oral administration were quoted from the literature as follows: acetaminophen [34], amitriptyline [35], antipyrine [36], atenolol [37], felodipine [38], fexofenadine [39], furosemide [40], midazolam and propranolol [7], nicardipine [41], nifedipine and timolol [42], pitavastatin [43], pravastatin [44], raloxifene [45], sulfasalazine [25] and verapamil [46]. Next, the cumulative amount of drug orally absorbed was calculated by the deconvolution method using Phoenix WinNonlin 6.4 from the plasma concentrations obtained by the IV and oral administrations.
Inter-subject variability in intestinal drug solubility
2015, International Journal of PharmaceuticsCitation Excerpt :It can be assumed that the physicochemical properties, especially the pH-dependent solubility, account for the high variable absorption, based on the results of this study. There have been reports of considerable intra- and inter-subject variability in furosemide bioavailability (Grahnén et al., 1984; Hammarlund et al., 1984; Murray et al., 1997; Smith et al., 1980; Waller et al., 1982). A major source of variation was attributed to the variation in the rate and extent of absorption, as the IV administration of preparations did not show extensive variability.
Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1: Oral solutions
2011, Journal of Pharmaceutical SciencesCitation Excerpt :Following oral administration, absorption of furosemide is incomplete and variable with an average bioavailability of 60%–70%.136,143,165 Furosemide simulation results were compared with experimental data presented by Waller et al.166 In this study, 18 fasted volunteers received 40 mg of furosemide as an i.v. injection over a 2‐min period and 4 mL of furosemide solution followed by 200 mL of water in a crossover design. Paracetamol (acetaminophen) is an analgesic and antipyretic drug used in mild to moderate pain and fever.126,127,143
Biowaiver monographs for immediate release solid oral dosage forms: Furosemide
2010, Journal of Pharmaceutical SciencesThe species differences of intestinal drug absorption and first-pass metabolism between cynomolgus monkeys and humans
2009, Journal of Pharmaceutical Sciences