ArticlesStereoselective pharmacokinetics of flurbiprofen in humans and rats
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Br. J. Clin. Pharmacol.
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Pharmacology of Analgesics
2023, Anesthesia and Analgesia in Laboratory AnimalsCorrelation between glucuronidation and covalent adducts formation with proteins of nonsteroidal anti-inflammatory drugs
2018, European Journal of Pharmaceutical SciencesCitation Excerpt :Furthermore, as the potency of glucuronidation varies with the NSAID (Magdalou et al., 1990), glucuronidation properties can affect subsequent covalent bond formation. Although most NSAIDs, particularly 2-arylpropanoic acids, are used as a racemate in clinical practice, stereoselective pharmacokinetics (Foster and Jamali, 1988; Iwaki et al., 1995; Jamali et al., 1988), glucuronidation (Ikuta et al., 2017; Chakir et al., 1994; Mano et al., 2007), protein binding (Bischer et al., 1995b), and mitochondrial toxicity (Browne et al., 1999) have been reported in enantiomers of NSAIDs. These results indicate that development of NSAIDs-induced liver injury can depend on stereoselective character of NSAIDs.
Flurbiprofen
2012, Profiles of Drug Substances, Excipients and Related MethodologyCitation Excerpt :Between 65% and 85% of flurbiprofen and its metabolites are present as glucuronide and sulfate conjugates. Stereoselective HPLC of human plasma has also been performed [137]. After oral administration of 25 mg of the R(−)-enantiomer of flurbiprofen, no indication was found that inversion to the S(+)-enantiomer occurred.
Flurbiprofen
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