ArticlesFetal and Maternal Placental and Nonplacental Clearances of Metoclopramide in Chronically Instrumented Pregnant Sheep
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Key Points in Fetal Drug Distribution
2017, Fetal and Neonatal Physiology, 2-Volume SetSimple HPLC method for determination of rosiglitazone in sheep plasma and amniotic fluid and its application in a pregnant sheep model
2011, Journal of Pharmaceutical and Biomedical AnalysisCitation Excerpt :Nevertheless, drugs can cross the placenta and pose a risk to the developing fetus. In the absence of other clearance mechanisms, the placenta plays a significant role in fetal drug clearance, and indeed many drugs, including labetalol [15], metoclopramide [16] and diphenhydramine [17], are preferentially transported from the fetus to the maternal circulation. The model used in this study is unusual in that the drug is dosed directly to the fetus, rather than to the ewe, with the intention of allowing the drug to accumulate and hence exert a sustained effect on fetal PPAR-γ receptors.
Drug Distribution in Fetal Life
2011, Fetal and Neonatal Physiology E-Book, Fourth EditionDrug Distribution in Fetal Life
2003, Fetal and Neonatal Physiology: Third EditionFetal hepatic drug elimination
1999, Pharmacology and TherapeuticsPharmacology of drug transfer across the placenta
1998, Obstetrics and Gynecology Clinics of North America
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