ArticlesRelative Lipophilicities, Solubilities, and Structure–Pharmacological Considerations of 3-Hydroxy-3-Methylglutaryl-Coenzyme A (HMG-CoA) Reductase Inhibitors Pravastatin, Lovastatin, Mevastatin, and Simvastatin
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Co-milling of β-cyclodextrin with simvastatin: Solid state studies and dissolution profile
2023, Journal of Drug Delivery Science and TechnologyFTIR spectroscopic study of two isostructural statins: Simvastatin and Lovastatin as authentic and in pharmaceuticals
2021, Spectrochimica Acta - Part A: Molecular and Biomolecular SpectroscopyFeasibility of the use of boron-doped diamond electrode coupled to electroanalytical techniques for the individual determination of pravastatin and its association with acetylsalicylic acid
2020, Journal of Electroanalytical ChemistryCitation Excerpt :The intersection of these two lines can be explained by the changes in protonation of the acid–base moiety in the molecule. The intersection point at pH 4.32 is attributed to the pKa value for PRAV, close to the one reported in the literature, which is related to the loss of a proton from the carboxyl group [35]. Concerning the peak currents, the higher oxidation peaks were obtained at pH 4.0 and 5.0; however, considering the repeatability of current intensity, pH 4.0 was selected for further experiments.
Differential effects of simvastatin on membrane organization and dynamics in varying phases
2019, Chemistry and Physics of LipidsInteraction of the cholesterol reducing agent simvastatin with zwitterionic DPPC and charged DPPG phospholipid membranes
2019, Biochimica et Biophysica Acta - BiomembranesCitation Excerpt :Under physiological pH conditions of 7–7·4, the relative lipophilicity of various statins currently in clinical use was: simvastatin ≈ cerivastatin > lovastatin ≈ fluvastatin ≈ atorvastatin ≫ pravastatin, where simvastatin is 100 times more lipophilic than pravastatin and pravastatin is 70- to 300-times more hydrophilic than the other statins [7]. The lipophilicity of statins provides a more uptake in peripheral tissues resulting in higher inhibition of cholesterol synthesis [10,11]. Simvastatin is one of the well clarified statins having high efficacy in reducing LDL cholesterol levels, high tolerability, and high capacity of cardiovascular risk and mortality reduction [12].
Liquid chromatography | Pharmaceutical applications
2019, Encyclopedia of Analytical Science