Regular ArticleMethionine Toxicity in the Rat in Relation to Hepatic Accumulation of S-Adenosylmethionine: Prevention by Dietary Stimulation of the Hepatic Transsulfuration Pathway
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Role of methionine on epigenetic modification of DNA methylation and gene expression in animals
2018, Animal NutritionCitation Excerpt :Consequently, the hepatic ratio of SAM to SAH increased 8 times in both 1.3% and 2.3% methionine diets, respectively, compared with control diet (Rowling et al., 2002). Similarly, an 80% increase of the hepatic ratio of SAM to SAH was observed following the 7 times of SAM and 4 times of SAH increases caused by a 1.5% dietary methionine intake (Regina et al., 1993). The 1.7% methionine diet increased the serum SAM, SAH and ratio of SAM to SAH, especially the serum SAH concentration, which was elevated by 2.28 folds (Yang et al., 2015).
Safety level evaluation of dietary 2-hydroxy-4-(methylthio) butanoic acid (HMTBa) for turbot Scophthalmus maximus based on growth performances, anti-oxidative responses, and liver and intestine conditions
2015, AquacultureCitation Excerpt :In addition, the utilization of high level of dietary HMTBa in turbot might accumulate more toxic metabolites in the liver, such as ketones and S-adenosylmethionine. These metabolites were reported to negatively affect the liver condition (Choo et al., 1991; Regina et al., 1993; Murthy and Varghese, 1998). When 1–5% HMTBa was added in the basal diet, the tissue injury in the liver was avoided and the integrity of liver structures was protected.
Total sulfur amino acid requirement and cystine replacement value for fingerling stinging catfish, Heteropneustes fossilis (Bloch)
2014, AquacultureCitation Excerpt :By virtue of their particular structural or metabolic features, methionine is the most toxic of the amino acids and excessive intake results in impaired growth and toxicity in various animal models (De Mello, 1994; Harper et al., 1970). Its toxicity is thought to be due to the accumulation of S-adenosylmethionine (SAM) in the liver (Regina et al., 1993). Methionine is recognized as the most growth-depressing amino acid when fed in huge excess to farm livestock (Baker, 2006) and various fish species (Borlongan and Coloso, 1993; Jackson and Capper, 1982; Kaushik and Luquet, 1980; Mai et al., 2006; Murthy and Varghese, 1998; Zhou et al., 2006).