Regular ArticleSteroid Metabolism by Rabbit Olfactory-Specific P450 2G1
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Pure human butyrylcholinesterase hydrolyzes octanoyl ghrelin to desacyl ghrelin
2015, General and Comparative EndocrinologyCitation Excerpt :This is far slower than the BChE turnover number of 34,000 min−1 for the smaller substrate butyrylthiocholine (Bartels et al., 2000). However, it is equivalent to the turnover numbers for the well-recognized P450 enzymes, e.g., P450 2B4 oxidizes 9-cis-retinal with a turnover number of 3.7 min−1 (Raner et al., 1996); and P450 2G1 oxidizes estradiol at 0.66 min−1, testosterone at 1.58 min−1, and progesterone at 1.66 min−1 (Ding and Coon, 1994). Thus hydrolysis at this rate would be well within the physiologically acceptable range.
Bioactivation of coumarin in rat olfactory mucosal microsomes: Detection of protein covalent binding and identification of reactive intermediates through analysis of glutathione adducts
2009, Chemico-Biological InteractionsCitation Excerpt :Forming a barrier between the external environment of the nasal cavity and the systemic circulation and adjacent brain tissue, the mammalian olfactory mucosa (OM) is unique relative to many other tissues in drug metabolism and toxicity perspectives, due to the presence of tissue-predominant (e.g., human CYP2A13, rat CYP2A3, mouse CYP2A5) and tissue-specific (e.g., rat and mouse CYP2G1) cytochrome P450s (CYPs) at a high expression level (pmol/mg protein) (reviewed in [1–3]). Teamed with high contents of NADPH-cytochrome P450 reductase (CPR) in the tissue, OM displays a substantial metabolic capacity toward endogenous steroids (e.g. testosterone and progesterone) [4,5] and a growing list of inhaled or systemically exposed olfactory toxicants and procarcinogens, such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), 2,6-dichlorobenzonitrile, acetaminophen (AP), coumarin, hexamethylphosphoramide and 2,6-diclorophenyl methylsulfone [2,6–11]. The high metabolic turnover rate in OM is generally believed to maintain homeostasis of the chemosensory tissue and protect the adjacent brain tissue from environmental insults [12].
High abundance of testosterone and salivary androgen-binding protein in the lateral nasal gland of male mice
2009, Journal of Steroid Biochemistry and Molecular BiologyCloning of CYP1A in Atlantic salmon (Salmo salar)
2005, AquacultureMouse Cyp2g1 gene: Promoter structure and tissue-specific expression of a Cyp2g1-LacZ fusion gene in transgenic mice
2001, Archives of Biochemistry and Biophysics