Regular ArticlecDNA Cloning, Heterologous Expression, and Characterization of Mouse CYP2G1, an Olfactory-Specific Steroid Hydroxylase☆
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Hepatic transcriptional profile and tissue distribution of cytochrome P450 1-3 genes in the red-crowned crane Grus japonensis
2020, Comparative Biochemistry and Physiology Part - C: Toxicology and PharmacologyCitation Excerpt :CYP2G19 is an avian specific gene for which the function is still unclear. Mouse Cyp2G1 was found to be uniquely expressed in the olfactory mucosa and to metabolize steroids, acetaminophen, and 2,6-dichlorobenzonitrile (Hua et al., 1997; Gu et al., 1998; Ling et al., 2004). In red-crowned crane, CYP2G19 was mainly expressed in the liver at a moderate level.
Mechanisms of olfactory toxicity of the herbicide 2,6-dichlorobenzonitrile: Essential roles of CYP2A5 and target-tissue metabolic activation
2010, Toxicology and Applied PharmacologyCitation Excerpt :Among the major nasal P450 enzymes, CYP1A2 and CYP2E1 have been suggested to be nonessential in the metabolic activation and toxicity of DCBN (Eriksson and Brittebo, 1995; Gu et al., 1998). A potentially significant role by CYP2G1, which is uniquely expressed in the OM (Hua et al., 1997), and was ~ 30% less efficient than CYP2A5 was in converting DCBN to GS-DCBN in vitro (Gu et al., 1998), has also been ruled out by our finding that a Cyp2g1-null mouse (Zhou et al., unpublished) was not protected from DCBN-induced nasal toxicity (data not shown). Results from these previous studies are consistent with the present finding that CYP2A5 plays a significant role in DCBN metabolism and toxicity in the OM.
High abundance of testosterone and salivary androgen-binding protein in the lateral nasal gland of male mice
2009, Journal of Steroid Biochemistry and Molecular BiologyRegulation of cytochrome P450 gene expression in the olfactory mucosa
2004, Chemico-Biological InteractionsCitation Excerpt :CYP2G1, CYP2A3, and CYP2A13 are examples of CYPs in the second group, which are predominantly or exclusively expressed in the OM. The expression of these genes appears to be more stringently regulated, especially for CYP2G1, which is expressed exclusively in the OM [4,61,62]. It is likely that tissue-enriched transcription factors play an important role in the transcriptional regulation of these genes.
Mouse Cyp2g1 gene: Promoter structure and tissue-specific expression of a Cyp2g1-LacZ fusion gene in transgenic mice
2001, Archives of Biochemistry and Biophysics
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This investigation was supported in part by NIH Grant DC02640.
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Current address: Department of Biochemistry, Nanjing University, Nanjing, P.R. China.
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To whom correspondence should be addressed at Wadsworth Center, New York State Department of Health, Empire State Plaza, Box 509, Albany, NY 12201-0509. Fax: 518-486-1505. E-mail: xinxin. [email protected].