Biochemical and Biophysical Research Communications
Volume 205, Issue 2, 15 December 1994, Pages 1064-1071
Regular ArticleInduction of CYP2E1 in Liver, Kidney, Brain and Intestine During Chronic Ethanol Administration and Withdrawal: Evidence That CYP2E1 Possesses a Rapid Phase Half-Life of 6 Hours or Less
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2020, Acta Pharmaceutica Sinica BCitation Excerpt :Thus, CYP2B1 and CYP2C11, in cultured rat hepatocytes treated with ALD inhibitors [3-methyladenine (3MA)/NH4Cl] or heterologously expressed in a vacuolar (lysosomal) degradation-deficient S. cerevisiae strain, are stabilized relative to those expressed in wild-type (WT) or proteasomal-subunit defective strains17,143,144. CYP2E1 degradation, on the other hand, is biphasic, exhibiting a rapid phase (t1/2, 7 h) and a slow phase (t1/2, 37 h) presumed to reflect its ERAD via UPD and ALD, respectively7,8,14. Upon substrate [isoniazid (INH) or acetone] induction, it largely incurs ALD7,17,139.
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