Regular ArticleThe Ah Receptor Recognizes DNA Binding Sites for the B Cell Transcription Factor, BSAP: A Possible Mechanism for Dioxin-Mediated Alteration of CD19 Gene Expression in Human B Lymphocytes
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Immunotoxicology of Halogenated Aromatic Hydrocarbons
2018, Comprehensive Toxicology: Third EditionA single mid-gestation exposure to TCDD yields a postnatal autoimmune signature, differing by sex, in early geriatric C57BL/6 mice
2011, ToxicologyCitation Excerpt :Functional or other changes in bone marrow B-lineage cells that may accompany these alterations in phenotypic distribution have not been studied but may be important. The molecular pathways controlling B cell lymphopoiesis, B-cell receptor (BCR) positive and negative selection processes, and B cell trafficking from bone marrow are mediated by several different bone marrow-level signal-transduction pathways (Monroe et al., 2003) and related proteins (e.g., NFκB, CD22, and CD19), which are affected by inappropriate activation of the aryl hydrocarbon receptor (AhR) (Masten and Shiverick, 1995; Tian et al., 1999). It is not yet known if these B cell pathways may be altered by prenatal TCDD and contributes to the observed autoimmune phenotype.
Pulmonary gene and microRNA expression changes in mice exposed to benzo(a)pyrene by oral gavage
2011, ToxicologyCitation Excerpt :It has been documented that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced suppression of IgM response is mediated through the activated AHR (Sulentic et al., 1998; Vorderstrasse and Kerkvliet, 2001). Masten and Shiverick (1995) showed that AHR negatively regulates Pax-5 (B cell lineage-specific activator protein)-stimulated CD19 gene transcription by competing to bind a common DNA binding site in human lymphocyte cell line treated with TCDD. A more recent study by De Abrew et al. (2010) identified 11 transcription factors and several genes known to regulate B-cell differentiation as targets of AHR in mouse B-cell line CH12.LX in response to TCDD exposure.
A constitutively active aryl hydrocarbon receptor causes loss of peritoneal B1 cells
2003, Biochemical and Biophysical Research CommunicationsCitation Excerpt :Although expression of CA-AhR in some way may be directly toxic to the CD5+ B1 cells, it is also possible that the CA-AhR can interfere with antigen receptor signaling. Interestingly, it has been shown that the Ah receptor ligand TCDD causes reduced expression of CD19 in a human B cell line [28]. Therefore, we have investigated CD19 expression on peripheral and bone marrow-derived B cells of adult CA-AhR mice as well as in livers from newborn mice.
Recent advances in understanding the mechanisms of TCDD immunotoxicity
2002, International Immunopharmacology