Biochemical and Biophysical Research Communications
Regular ArticleA Species Comparison of Chloral Hydrate Metabolism in Blood and Liver
References (0)
Cited by (32)
Injectable anesthetics
2023, Anesthesia and Analgesia in Laboratory AnimalsTrichloroethylene biotransformation and its role in mutagenicity, carcinogenicity and target organ toxicity
2014, Mutation Research - Reviews in Mutation ResearchCitation Excerpt :CHL/CH undergoes either a reduction by alcohol dehydrogenase (ADH) [23] or CYP [24,25] to generate trichloroethanol (TCOH). Oxidation of CHL/CH by aldehyde dehydrogenase (ALDH) results in formation of trichloroacetic acid (TCA) [26,27]. Rapid metabolism of CHL/CH in the liver, where the enzymes that participate in further metabolism are abundant, likely explains its detection in smaller amounts than in other tissues (e.g., lung) [10].
Modulation of trichloroethylene in vitro metabolism by different drugs in human
2014, Toxicology in VitroCitation Excerpt :Published results by Lipscomb et al. (1998a) illustrate such expression discrepancy for CYP 2E1; one of the main enzymes involved in TCE biotransformation, which has been found to be very high in rat compared to human. Lipscomb et al. (1996) reported also that, compared to rat, CH biotransformation into TCOH in human is only half of what was observed in animal, but TCA elimination is three times higher. Finally, Lash et al. (2000) revealed that expression level of carriers is 10 times higher in human compared to rat.
Pharmacology of Injectable Anesthetics, Sedatives, and Tranquilizers
2008, Anesthesia and Analgesia in Laboratory AnimalsLack of formic acid production in rat hepatocytes and human renal proximal tubule cells exposed to chloral hydrate or trichloroacetic acid
2007, ToxicologyCitation Excerpt :The metabolism of CH to TCE-OH by rat hepatocytes became saturated at high substrate concentration while metabolism to TCA did not (Fig. 5). These findings are in good agreement with those reported by Lipscomb et al. (1996) for rat and human liver fractions and also closely resemble that seen in vivo in rats exposed to TCE (Prout et al., 1985). We report for the first time that HRPTC can metabolise CH to TCE-OH and TCA.
Lipid peroxidation and cell death mechanisms in rats and human cells induced by chloral hydrate
2003, Food and Chemical Toxicology
- 1
Author to whom correspondence should be addressed at: USAF, BSC, Toxicology Division, OL-AL HSC/OET, 2856 G Street, Wright-Patterson AFB, OH 45433-7400. Fax: (513) 255-1474. E-mail: JLipscomb@AL. WPAFB.AF.MIL.