Biochemical and Biophysical Research Communications
Regular ArticleDifferential Effects of Interleukin-1β, Interleukin-2, and Interferon-γ on the Inducible Expression of CYP 1A1 and CYP 1A2 in Cultured Rabbit Hepatocytes☆
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2001, Journal of Biological ChemistryCitation Excerpt :In agreement, cooperative enhancement of the endogenous AhRR mRNA expression was actually observed in HeLa cells treated with 3MC and TPA (Fig.6 b). Finally, several cytokines such as interleukin-1β, tumor necrosis factor, and interferon-γ are reported to inhibit induced expression of CYP1A1 and CYP1A2 genes (33, 34). Since NF-κB is known to work as a downstream effector of these cytokines (35), the inhibitions of cytochrome P450 induction could be explained through the enhanced synthesis of AhRR by NF-κB.
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IL-1β, interleukin-1βIL-2, interleukin-2; IFN-γ, interferon-γ; P450, cytochrome P450; CYP1A1, gene encoding for P4501A1 isoenzyme; TBZ, thiabendazole; BNF, β-naphtoflavone; EROD, ethoxyresorufin O-deethylase; MROD, methoxyresorufin O-demethylase; LDH, lactate dehydrogenase; DMSO, dimethylsulfoxide; GAPDH, glyceraldehyde phosphate dehydrogenase; FCS, fetal calf serum; SDS-PAGE, sodium dodecylsulfate-polyacrylamide gel electrophoresis;
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