Biochemical and Biophysical Research Communications
Regular ArticleInduction of CYP1A1 by Serum Independent of AhR Pathway
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2019, International Journal of PharmaceuticsCollagen density regulates xenobiotic and hypoxic response of mammary epithelial cells
2015, Environmental Toxicology and PharmacologyCitation Excerpt :Lastly, in Fig. 4E–H, we show that both DFOM and tranilast enhanced CYP1A1 and CYP4B1 expression in the MCF10A cell line. Thus, unlike VEGF production and the HRE response (Figs. 1–3), the regulation of P450 enzymes does not match the XRE response, suggesting that in non-tumorigenic cells, additional cell signals other than the AhR:ARNT pathway, may also play role in the regulation of P450 expression as has been previously explored (Guigal et al., 2000; Mastyugin et al., 2004; Zordoky and El-Kadi, 2009; Villard et al., 2011). To examine the mechanisms of P450 and VEGF expression in collagen, downstream signals associated with cell adhesion to collagen were assessed.
Fetal bovine serum and human constitutive androstane receptor: Evidence for activation of the SV23 splice variant by artemisinin, artemether, and arteether in a serum-free cell culture system
2014, Toxicology and Applied PharmacologyCitation Excerpt :In another study, hexanal, a peroxidation product of linoleic acid in FBS, was reported to activate peroxisome proliferator-activated receptor α (Villard et al., 2011), and this leads to an increase in peroxisome proliferator-activated receptor α-mediated induction cytochrome P450 1A1 (Villard et al., 2011). In contrast, FBS does not activate the aryl hydrocarbon receptor (Guigal et al., 2000; Guigal et al., 2001), which is a principal regulator of cytochrome P450 1A1 (Kohle and Bock, 2009). Overall, it appears that FBS selectively activates receptors by the action of various chemicals, including specific contaminants and metabolic breakdown products present in the serum.
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