Regular ArticleCloning of the Full-Length Coding Sequence of Rat Liver-Specific Organic Anion Transporter-1 (rlst-1) and a Splice Variant and Partial Characterization of the Rat lst-1 Gene☆
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Cited by (34)
Elucidation of OATP1B1 and 1B3 transporter function using transgenic rodent models and commonly known single nucleotide polymorphisms
2020, Toxicology and Applied PharmacologyCitation Excerpt :The same group (Kakyo et al., 1999) reported the cloning of rlst-1 (rat lst-1). However, it turned out to be a splice variant; and soon thereafter the cloning of both full-length rat lst-1 (rlst-1) and mouse lst-1 (mlst-1) was reported (Choudhuri et al., 2000; Ogura et al., 2000). Choudhuri et al. (2000) reported the cloning of a new splice variant of rlst-1.
Organic anion transporting polypeptides in the hepatic uptake of PBDE congeners in mice
2011, Toxicology and Applied PharmacologyCitation Excerpt :In contrast to its murine orthologs, OATP1A2 expression in the liver is restricted to the epithelial cells of the bile duct (Lee et al., 2005). Oatp1b2 is the ortholog of both human OATP1B1 and OATP1B3 whereas Oatp2b1 is the mouse ortholog of human OATP2B1 (Cattori et al., 2000; Choudhuri et al., 2000; Meyer Zu Schwabedissen et al., 2009; Ogura et al., 2000). In general, Oatp1a1, Oatp1a4, and Oatp1b2 demonstrate overlapping substrate specificity and transport substrates like taurocholic acid, sulphobromopthalein, and estrone-3-sulfate (Hagenbuch et al., 2000; Meyer Zu Schwabedissen et al., 2009; van Montfoort et al., 2002).
Endogenous drug transporters in in vitro and in vivo models for the prediction of drug disposition in man
2002, Biochemical PharmacologyCitation Excerpt :OATP-C was detected in all liver samples but unexpectedly also in canine kidney and in the cell lines derived from it (Table 1). It is unusual that OATP-C was expressed in the canine kidney, as the transporter protein was discovered to be liver-specific in the human [27], rat and mouse [28]. Nevertheless, the levels of functional OATP-C in canine kidney may still be low and need to be confirmed by immunohistochemical staining.
Diverse eukaryotic transcripts suggest short tandem repeats have cellular functions
2002, Biochemical and Biophysical Research CommunicationsCitation Excerpt :Hydrophilicity plots of the coding sequences revealed that four (25%) of the 16 membrane-associated peptides had extensive hydrophobic sequences consistent with integral membrane localization. These included the nicotinic acetylcholine receptor, bile acid transporter [6], organic anion transporter [7], and red cone visual pigment proteins [8]. The remaining 11 of 16 had limited hydrophobic domains but were known to interact with membranes or structures directly associated with membranes.
Differential gene expression of organic anion transporters in male and female rats
2002, Biochemical and Biophysical Research Communications
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Full-length sequence information have been submitted to the GenBank nucleotide sequence database under the Accession Nos. AF208545, AF217450, and from AF272557 to AF272571.
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Present address: Department of Drug Metabolism and Molecular Toxicology, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.