Biochemical and Biophysical Research Communications
Regular ArticleMicroarray Analysis of Gene Expression Changes in Mouse Liver Induced by Peroxisome Proliferator- Activated Receptor α Agonists
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Vanin1 (VNN1) in chronic diseases: Future directions for targeted therapy
2024, European Journal of PharmacologyHigh-fat diet affects gut nutrients transporters in hypo and hyperthyroid mice by PPAR-a independent mechanism
2018, Life SciencesCitation Excerpt :The time and dosage of PTU and T3 used were based in previous studies [17,18]. Control mice fed LFD or HFD received saline as vehicle.Moreover, we also evaluate the impact of fenofibrate, a PPAR-alpha agonist on the small intestine of mice.For that, mice fed with LFD were once daily treated with fenofibrate from Sigma-Aldrich (100 mg/Kg) or sorbitol (vehicle) by gavage, for 12 days [19]. All mice were euthanized at six- month of age by decapitation, under isoflurane inhalation anesthesia.
Analysis of gene expression profiles in response to Sporisorium reilianum f. sp. zeae in maize (Zea mays L.)
2014, Electronic Journal of BiotechnologyPPAR-alpha dependent regulation of vanin-1 mediates hepatic lipid metabolism
2014, Journal of HepatologyCitation Excerpt :In addition, PPARα has emerged as a crucial transcriptional regulator of numerous other metabolic processes including metabolism of glucose, cholesterol, bile acids, and amino acids [4–6]. Several different research groups have identified vanin-1 as an important PPARα-target gene [3,7–9] and showed that production of vanin-1 depends on PPARα activity [7]. However, despite the observations that vanin-1 is highly expressed in the liver as compared to other tissues [10,11], little is known about its actual role in hepatic lipid metabolism.
PPARalpha regulates the production of serum Vanin-1 by liver
2013, FEBS LettersCitation Excerpt :In adult tissues, Vnn1 is heterogeneously expressed by epithelial tissues [10] and its expression level is modulated by stress [11,12]. Microarray analyses have shown that PPARα activation lead to upregulated Vnn1 gene expression [13,14]. Using Vnn1 deficient mice, we showed that Vnn1 regulates gut inflammation [3,15].
PPAR-α as a key nutritional and environmental sensor for metabolic adaptation
2013, Advances in Nutrition
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