Regular ArticleHuman Carbonyl Reductase (CBR) Localized to Band 21q22.1 by High-Resolution Fluorescence in Situ Hybridization Displays Gene Dosage Effects in Trisomy 21 Cells
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Lipid peroxidation and neurodegenerative disease
2011, Free Radical Biology and MedicineCitation Excerpt :Recently this enzyme was found to be modified in persons with corticobasal degeneration, a neurological disorder whose symptoms closely mirror those of Parkinson disease [228]. The gene for carbonyl reductase is located in close proximity to the gene for Cu/Zn superoxide dismutase [229]. Interestingly, the genes for SOD1, carbonyl reductase, and APP are located on chromosome 21, which is a trisomy in Down syndrome patients [230,231].
Redox proteomic identification of 4-Hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: Insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer's disease
2008, Neurobiology of DiseaseCitation Excerpt :Carbonyl reductase expression is altered in Down's syndrome and AD patients (Balcz et al., 2001). The gene for carbonyl reductase is located in close proximity to the gene for Cu/Zn superoxide dismutase (SOD1) (Lemieux et al., 1993). Interestingly, the genes for SOD1, carbonyl reductase, and APP are located on chromosome 21, which is a trisomy in Down's syndrome patients (Korenberg et al., 1992).
Down syndrome, antioxidant balance and the “gene dosage effect” hypothesis
2007, Oxidative Stress and Neurodegenerative DisordersRole of oxidative stress in neurodegeneration: Recent developments in assay methods for oxidative stress and nutraceutical antioxidants
2004, Progress in Neuro-Psychopharmacology and Biological PsychiatryFurther characterization of Chinese hamster carbonyl reductases (CHCRs)
2003, Chemico-Biological InteractionsCitation Excerpt :Expression of these multiple forms of CRs has been reported in a variety of organisms including human, rat, Chinese hamster, chicken and rainbow trout [6,15,17,19,20,22–25]. There is also recent evidence for the expression of multiple CR genes on human chromosome 21, and in the Chinese hamster genome [14,26–29]. These findings imply the existence of mechanisms regulating the expression of multiple CR forms.
Cytotoxicity of daunorubicin in trisomic (+21) human fibroblasts: Relation to drug uptake and cell membrane fluidity
2001, Cell Biology International