Regular ArticleAntibody-Defined Epitope Mapping Using the Multipin Method of Peptide Synthesis
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Cited by (25)
Primary biliary cirrhosis following lactobacillus vaccination for recurrent vaginitis
2008, Journal of HepatologyCitation Excerpt :We present the case of a woman with an 8-year history of lactobacillus vaccination for recurrent vaginitis who developed characteristic clinical, biochemical and histological features of primary biliary cirrhosis. In view of known immunological cross-reactivity between a lactobacillus sequence and the major autoepitope of antimitochondrial antibody [11] we characterized autoreactivity and possible cross-reactivity [11,18,19,21,22,24–27,30] in this patient finding that her serum contains a high-titer AMA, which belongs mainly to IgG3 subclass and targets the immunodominant PDC-E2212–226 autoepitope. This serum also reacts with the Lactobacillus delbrueckii subs.
Mapping of FVIII inhibitor epitopes using cellulose-bound synthetic peptide arrays
2006, Journal of Immunological MethodsSusceptibility to thyroid disorders in hepatitis C
2005, Clinical Gastroenterology and HepatologyBiosensor Characterization of Structure-Function Relationships in Viral Proteins
2004, Methods in MicrobiologyCitation Excerpt :In rare instances will a linear peptide fragment contain a sufficient number of residues of the original discontinuous epitope to enable it to bind to antibodies raised against the intact protein. Nowadays, continuous epitopes of proteins are frequently identified by analysing the antigenic reactivity of sets of overlapping synthetic peptides encompassing the entire sequence of the protein antigen (Rodda and Tribbick, 1996). Another approach consists in testing the antigenic reactivity of sets of peptides obtained from a combinatorial library.