Regular ArticleMycobacterial cell wall components induce the production of TNF-α, IL-1, and IL-6 by bovine monocytes and the murine macrophage cell line RAW 264.7
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Characterization and pathogenicity of extracellular serine protease MAP3292c from Mycobacterium avium subsp. paratuberculosis
2020, Microbial PathogenesisCitation Excerpt :The expression levels of IL-1β, TNF-α, and IL-6 significantly increased in the infected ovine intestinal tissues by MAP [29]. MAP and CW components induce the expression of TNF-α and IL-6 in bovine monocytes [30]. TNF-α activates naive macrophages and is essential for the formation of granulomas around the sites of mycobacterial infection [31].
Commercial naphthenic acids and the organic fraction of oil sands process water downregulate pro-inflammatory gene expression and macrophage antimicrobial responses
2011, Toxicology LettersCitation Excerpt :We analyzed the expression of different macrophage-activating cytokine genes in the spleen. Cytokines such as TNFα, IFNγ, IL-1β, and CSF-1 are produced by monocytes/macrophages, and also by other cell types (Adams and Czuprynski, 1994; Lee et al., 1990; Mosser and Edwards, 2008; Vellenga et al., 1988; Xing, 2000), and influence the ability of macrophages to perform immune functions (Mosser and Edwards, 2008). Oral exposure of mice to OSPW-OF at 100 mg/kg NAs for 8 weeks resulted in down regulation of IFNγ, IL-1β, and CSF-1 (Fig. 10A).
Extracts from Citrus unshiu promote immune-mediated inhibition of tumor growth in a murine renal cell carcinoma model
2011, Journal of EthnopharmacologyEstablishment of Mycobacterium avium subsp. paratuberculosis infection in the intestine of ruminants
2004, Advanced Drug Delivery Reviews