Regular ArticleCresol Isomers: Comparison of Toxic Potency in Rat Liver Slices
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Phenolic compounds as controllers of Sitophilus zeamais: A look at the structure-activity relationship
2022, Journal of Stored Products ResearchCitation Excerpt :The compounds m-cresol, vanillin, and phenol had low toxicity (LC50 between 400 and 600 μmol/cm2), with the first one being the least toxic compound. While for p-cresol, guaiacol, and the aromatic hydrocarbon p-cymene we observed a medium toxicity, as has been described in numerous previous works (Dele, 2020; Ho et al., 2011; Martínez Enriquez et al., 2009; Tavares et al., 2013; Thompson et al., 1994), the compounds o-cresol, thymol, and carvacrol showed values of LC50 < 250 μmol/cm2, and were the most toxic in this group of compounds studied. The compound creosol did not show a linear correlation between concentration and toxicity, therefore LC50 could not be determined.
A targeted ultra performance liquid chromatography – Tandem mass spectrometric assay for tyrosine and metabolites in urine and plasma: Application to the effects of antibiotics on mice
2021, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life SciencesImmobilization of laccase of Pycnoporus sanguineus CS43
2017, New BiotechnologyMetabolic Activation and Toxicities of bis-Benzylisoquinoline Alkaloids
2017, Advances in Molecular ToxicologyCitation Excerpt :For example, bromide, a good leaving group, efficiently generates QMs under physiological conditions [68]. The formation of QMs in vitro and in vivo has been linked to cytotoxicity, for instance, in hepatocytes [67,70], liver slices [71,72], bronchiolar Clara cells [73], lung epithelial cell [74], and keratinocytes from mice or rats [75,76]. Data from in vivo studies implicated that QMs could cause hepatotoxicity [77–80], pulmonary toxicity [81–83], tumor promotion [84–86], and carcinogenicity [87,88].
Comprehensive composition of Creosote using comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry (GCxGC-TOFMS)
2017, ChemosphereCitation Excerpt :Since the sample has been previously shown to be heavily weathered (McGregor et al., 2011) one possible explanation for the low concentrations of Phenol and Cresols is their aqueous solubility, although volatility may also play a role through volatilization into the air surrounding the sump. p-Cresol, which is present at a concentration of 112 mg/kg is the most toxic of the cresol isomers with a 5–10-fold concentration of either o-cresol or m-cresol being needed to observe the same degree of toxicity as p-cresol (Thompson et al., 1994). This means that although p-cresol has the lowest concentration of the cresol isomers it would have the environmental highest risk associated with it.