Regular ArticleImmunohistochemical Localization of CYP1A-Like and CYP3A-like Isozymes in Hepatic and Extrahepatic Tissues of Atlantic Cod (Gadus morhua L), a Marine Fish
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2023, Comparative Biochemistry and Physiology - Part D: Genomics and ProteomicsChronic toxicity of tire crumb rubber particles to mummichog (Fundulus heteroclitus) in episodic exposures
2022, Science of the Total EnvironmentCitation Excerpt :Weaker CYP1A induction in intestinal epithelium as observed in the current study may be a result of a short residence time of CR particles in the gut, or other factors that prevent transfer of PAHs to the intestinal cells. The observed weak positive staining for CYP1A in mucosal epithelial cells in the present study is corroborated by Husøy et al. (1994) who observed no CYP1A expression in mucosal cells in cod intraperitoneally injected with β-naphthoflavone and Van Veld et al. (1997) who observed low positive staining for CYP1A in F. heteroclitus after aqueous exposure to benzo[a]pyrene (BaP). Nevertheless, in the same study, Van Veld et al. (1997) also found that F. heteroclitus exposed to BaP via diet showed strong CYP1A staining in gut mucosal epithelium, indicating that route of exposure may play a significant role in the metabolism for PAH-type compounds.
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2019, Toxicology and Applied PharmacologyCYP1A gene expression as a basic factor for fipronil toxicity in Caspian kutum fish
2018, Toxicology ReportsCitation Excerpt :Histological alterations in the kidney was only observed in the renal tubule and not in glomeruli and hematopoietic tissue. Interestingly, previous studies on immunohistochemical localization of CYP1A in the fish kidney showed that this enzyme had the most distribution in the renal tubular epithelium and the least distribution in glomeruli and hematopoietic tissue [44,45]. The increase of DTC in this organ in dose dependent manner is probably related to concentrating fipronil and its metabolites in the renal tubule.