Regular ArticleRat Hepatocytes with Elevated Metallothionein Expression Are Resistant toN-Methyl-N′-nitro-N-nitrosoguanidine Cytotoxicity
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The fungicide thiabendazole causes apoptosis in rat hepatocytes
2016, Toxicology in VitroCitation Excerpt :Fractions of apoptotic and necrotic cells were determined relative to total cells. Hepatocytes were exposed to thiabendazole (100–500 μM) for 24 h and 48 h, and the release of LDH into culture medium was assessed at 24 h intervals of time, from 0 to 24 h and from 24 to 48 h (Moldeus et al., 1978; Moffatt et al., 1996). After 24 h, fresh medium and drug were added to hepatocytes and LDH was analyzed in the medium after a further interval of 24 h.
Cadmium inhibits human DNA mismatch repair in vivo
2004, Biochemical and Biophysical Research CommunicationsCitation Excerpt :However, the level of MT does not seem to parallel the degree of protection from MNNG [16]. On the other hand, Zn pretreatment causing a concentration-dependent increase in MT was indeed able to protect cells from MNNG-induced killing [17]. If MT is responsible for the phenotypes presented in this work, we would expect to see a protective effect of Zn on MNNG-induced cell cycle effects.
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