Regular ArticleCorrelation of 2,3,7,8-Tetrachlorodibenzo-p-dioxin Induction of Cytochrome P4501A in Vascular Endothelium with Toxicity in Early Life Stages of Lake Trout☆,☆☆
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2022, Science of the Total Environment2,3,7,8-Tetrachlorodibenzo-p-dioxin exposure disrupts development of the visceral and ocular vasculature
2021, Aquatic ToxicologyCitation Excerpt :Given the role of AHR in vascular development, it has long been proposed that the developing vasculature is a primary target for xenobiotic compounds that act as exogenous AHR ligands (Hankinson, 1995; Schmidt and Bradfield, 1996; Prasch et al., 2003, 2006). Consistent with this hypothesis, exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), a potent AHR agonist and a global environmental contaminant, induces vascular expression of cytochrome P4501A (cyp1a), a widely accepted biomarker of AHR activation (medaka: Cantrell et al., 1996, lake trout: Guiney et al., 1997, killifish: Toomey et al., 2001, and zebrafish: Andreasen et al., 2002). In zebrafish, TCDD exposure induces cyp1a mRNA in the endothelium as early as 24 hours post fertilization (hpf), preceding any signs of toxicity (Andreasen et al., 2002).
Oil sands tailings pond sediment toxicity to early life stages of northern pike (Esox lucius)
2018, Science of the Total EnvironmentCitation Excerpt :Exposure to sediments from tailings ponds and natural river sediments increased embryo-larval mortality and the incidence of abnormalities in early life stages of white sucker (Catostomus commersoni) and fathead minnows (Pimephales promelas) was associated with alkylated PAHs (Colavecchia et al., 2004, 2006). Many studies show that early life stages of fish are especially sensitive to the effects of alkylated PAHs and PAHs in weathered crude oil and oil sands related samples (Guiney et al., 1997; Marty et al., 1997a, 1997b; Carls et al., 1999; Couillard, 2002; Rhodes et al., 2005; Sorhus et al., 2017). Early life stages of fish exposed to alkylated PAH mixtures in crude oil show similar developmental malformations (such as craniofacial deformities, hemorrhages and edema) as fish exposed to oil sands sediments (Marty et al., 1997a, 1997b; Carls et al., 1999; Couillard, 2002; Colavecchia et al., 2004, 2006; Raine et al., 2017b; Sorhus et al., 2017).
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Preliminary results of this research were presented at the 13th Annual Meeting of the Society of Environmental Toxicology and Chemistry Meeting, Cincinnati, OH, November 8–12, 1992.
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E. K. Balon, Ed.
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Present Address: S. C. Johnson and Son, Inc., 1525 Howe St., Racine, WI 53403.
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To whom correspondence should be addressed at Redfield 342, Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543. E-mail: [email protected].