Regular ArticleHydroxylated Polychlorinated Biphenyls (PCBs) as Estrogens and Antiestrogens: Structure–Activity Relationships☆
References (51)
- et al.
Heterologous expression of human uteroglobin/polychlorinated biphenyl-binding protein
J. Biol. Chem.
(1994) - et al.
Binding of polychlorinated biphenyls classified as either phenobarbitone-, 3-methylcholanthrene-, or mixed-type inducers to cytosolic Ah receptor
Chem.-Biol. Interact.
(1982) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
Anal. Biochem.
(1976)- et al.
Study on the mechanism of interference of 3,4,3′,4′-tetrachlorobiphenyl with the plasma retinol-binding proteins in rodents
Chem.-Biol. Interact.
(1988) - et al.
Binding of a metabolite of 3,4,3′,4′-tetrachlorobiphenyl to transthyretin reduces serum vitamin A transport by inhibiting the formation of the protein complex carrying both retinol and thyroxin
Toxicol. Appl. Pharmacol.
(1986) - et al.
Human estrogen receptor multiple protein-DNA complexes
J. Biol. Chem.
(1990) - et al.
Structure-dependent induction of CYB2B by polychlorinated biphenyl congeners in female Sprague-Dawley rats
Biochem. Pharmacol.
(1995) - et al.
Relative tumour promoting activity of three polychlorinated biphenyls in rat liver
Eur. J. Pharmacol.
(1993) - et al.
Estrogen action in target cells: Selective requirements for activation of different hormone response elements
Mol. Cell. Endocrinol.
(1995) - et al.
Chimeric receptor genes as a tool for measuring biological activities of steroid hormones
J. Biolum. Chem.
(1994)
Comparative effects of two polychlorinated biphenyl congeners on calcium homeostasis in rat cerebellar granule cells
Toxicol. Appl. Pharmacol.
Increased [3
Toxicol. Appl. Pharmacol.
Structure-dependent competitive interaction of hydroxy-polychlorobiphenyls, -dibenzo-p
Chem.-Biol. Interact.
The nuclear receptor superfamily: The second decade
Cell
Antiestrogenicity activity of hydroxylated PCBs identified in human serum
Toxicol. Appl. Pharmacol.
Immunochemical quantitation of cytochrome P-450 isozymes and epoxide hydrolase in liver microsomes from polychlorinated and polybrominated biphenyls: A study of structure activity relationships
J. Biol. Chem.
Synthesis and characterization of hydroxylated polychlorinated biphenyls (PCBs) identified in human serum
Chemosphere
Lightly chlorinatedortho
Toxicol. Appl. Pharmacol.
Comparison of effects of Aroclors 1016 and 1260 on non-human primate catecholamine function
Toxicology
Assessing the estrogenic and dioxin-like activities of chemicals and complex mixtures usingin vitro
Can. J. Physiol. Pharmacol.
Chemical properties, analytical and environmental levels of PCBs, PCTs, PCNs and PCBs
Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products
Effect of dietary retinyl palmitate on the promotion of altered hepatic foci by 3,3′,4,4′-tetrachlorobiphenyl and 2,2′,4,4′,5,5′-hexachlorobiphenyl in rats initiated with diethylnitrosamine
Carcinogenesis
Selective retention of hydroxylated PCB metabolites in blood
Environ. Health Perspect.
Target cells for the polychlorinated biphenyl metabolite 4,4′-bis(methylsulfonyl)-2,2′,5,5′-tetrachlorobiphenyl in lung and kidney
Drug Metab. Dispos.
Optimized use of the firefly luciferase assay as a reporter gene in mammalian cell lines
Biotechniques
Cited by (217)
Metabolism vs. metabolomics: Mechanisms of endocrine disruption
2023, Environmental Contaminants and Endocrine HealthComparative transcriptomic analysis reveals reproductive impairments caused by PCBs and OH-PCBs through the dysregulation of ER and AR signaling
2022, Science of the Total EnvironmentA computational insight into endocrine disruption by polychlorinated biphenyls via non-covalent interactions with human nuclear receptors
2021, Ecotoxicology and Environmental SafetyCitation Excerpt :It was also reported by Salama et al. (2003) that Aroclor 1221 (a commercial mixture of PCBs) exhibits estrogenic activity through direct binding to ER β. Furthermore, PCBs undergo biotransformation in humans and other biota to give stable metabolites that activate or antagonize AR and ERs by direct binding (Jansen et al., 1993; Connor et al., 1997; Kuiper et al., 1998; Arulmozhiraja et al., 2005; Takeuchi et al., 2011; Grimm et al., 2015). Binding of PCBs or their metabolites to AR and ERs may be useful in explaining some of the adverse effects of PCBs on male and female reproductive health.
Associations between intrauterine exposure to polychlorinated biphenyls on neonatal ano-genital distance
2020, Reproductive ToxicologyCitation Excerpt :These compounds also pass through the placenta, so fetuses are exposed in-utero [2]. Stereochemically, many PCBs resemble steroid hormones, including estrogen and testosterone [3]. Data from animal studies indicate that these compounds act as endocrine disruptors [4,5], raising concerns of the effects of exposure on human reproductive and neurological development.
- ☆
R. D. KimbroughA. A. Jensen, Eds.
- 1
To whom correspondence should be addressed. Fax: (409) 862-4929. E-mail: [email protected].