Regular ArticleIn Vitrotoin VivoExtrapolation for Trichloroethylene Metabolism in Humans☆
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2018, Toxicology LettersCitation Excerpt :Furthermore, Reynaud et al. (2012) observed an increase in bioconcentration factor for FIP over six days in green frogs, which was the opposite of the current study. Extrapolation from Vmax in vitro liver microsomes to Vmax in vivo for risk assessments was similar to the method in Lipscomb et al. (1998) (Table 2). DIA and DEA had the lowest values at 0.47 and 0.46 mg h−1 kg−1, respectively, while the highest value was for TDN at 2.38 mg h−1 kg−1.
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A. M. Goldberg
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