Regular ArticleIn VitroMetabolism of Chlorotriazines: Characterization of Simazine, Atrazine, and Propazine Metabolism Using Liver Microsomes from Rats Treated with Various Cytochrome P450 Inducers☆
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2018, Toxicology LettersCitation Excerpt :Therefore, the skin is presumed to be the major route of exposure for contaminants in amphibians compared to pulmonary and oral routes (Smith et al., 2007). After entering the body, pesticide metabolism is commonly initiated by the liver, where phase I proteins such as cytochrome P450 enzymes are used to help with the oxidation, reduction, and hydrolysis of xenobiotics (Lang et al., 1996; Hanioka et al., 1999a). In in vitro exposures, liver degraded atrazine into two major metabolites: desethyl atrazine and deisopropyl atrazine in rats, guinea pigs, goats, rabbits and humans (Adams et al., 1990; Lang et al., 1996; Hanioka et al., 1999b).
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M. R. WatermanE. F. Johnson
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