Summary
Twenty children undergoing surgery received a lumbar block using 0.4 ml/kg mepivacaine 2.0%. They were randomized into two groups, one of which received midazolam 0.4 mg/kg rectally as premedication. Midazolam administration did not significantly influence the plasma concentrations of mepivacaine.
References
Giaufre E, Bruguerolle B, Morisson-Lacombe G, Rousset-Rouvière B (1988) The influence of diazepam on the plasma concentrations of bupivacaine and lignocaine after caudal injection of a mixture of the local anaesthetics in children. Br J Clin Pharmacol 26: 116–118
Giaufre E, Bruguerolle B, Morisson-Lacombe G, Rousset-Rouvière B (1989) The influence of midazolam on the plasma concentrations of bupivacaine and lidocaine after caudal injection of a mixture of the local anaesthetics in children. Acta Anaesthesiol Scand 33
Prat M, Bruguerolle B (1987) Etude pharmacocinétique de la bupivacaine chez la souris: proposition d'une technique specifique et sensible par chromatographie gazeuse. Pathol Biol 35: 1271–1275
Scott D (1975) Evaluation of clinical tolerance of local anaesthetic agents. Br J Anaesth 47: 328–331
Smith MJ, Heazlewood W, Eadie MJ, O'Rourke-Brophy T (1981) The pharmacokinetics of midazolam in man. Eur J Clin Pharmacol 19: 271–278
Takasaki M (1984) Blood concentrations of lidocaine, mepivacaine and bupivacaine during caudal analgesia in children. Acta Anaesthesiol Scand [Suppl] 28: 211–214
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Giaufre, E., Bruguerolle, B., Morisson-Lacombe, G. et al. Influence of midazolam on the plasma concentrations of mepivacaine after lumbar epidural injection in children. Eur J Clin Pharmacol 38, 91–92 (1990). https://doi.org/10.1007/BF00314812
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00314812