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Influence of midazolam on the plasma concentrations of mepivacaine after lumbar epidural injection in children

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Summary

Twenty children undergoing surgery received a lumbar block using 0.4 ml/kg mepivacaine 2.0%. They were randomized into two groups, one of which received midazolam 0.4 mg/kg rectally as premedication. Midazolam administration did not significantly influence the plasma concentrations of mepivacaine.

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References

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Giaufre, E., Bruguerolle, B., Morisson-Lacombe, G. et al. Influence of midazolam on the plasma concentrations of mepivacaine after lumbar epidural injection in children. Eur J Clin Pharmacol 38, 91–92 (1990). https://doi.org/10.1007/BF00314812

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  • DOI: https://doi.org/10.1007/BF00314812

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