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Steady state disposition of chloroquine in patients with rheumatoid disease

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Summary

The steady state disposition of chloroquine and its major metabolites, monodesethyl and bidesethyl chloroquine, were determined in 6 patients on long-term treatment for rheumatic disease with 99–155 mg base/day. The total body clearance of chloroquine was 0.35 l/kg/h and that of its metabolites was much higher. The renal clearance was the same for all compounds measured, ≈0.1 l/kg/h. Currently recommended dosage schedules appear to be too high in certain cases.

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Authors and Affiliations

  1. Section of Clinical Pharmacology and Medical Pharmacology, Uppsala University, Uppsala, Sweden

    M. Frisk-Holmberg

  2. Department of Clinical Chemistry and Rheumatology, Falu Central Hospital, Falun, Sweden

    Y. Bergqvist & B. Domeij-Nyberg

Authors
  1. M. Frisk-Holmberg
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  2. Y. Bergqvist
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  3. B. Domeij-Nyberg
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Frisk-Holmberg, M., Bergqvist, Y. & Domeij-Nyberg, B. Steady state disposition of chloroquine in patients with rheumatoid disease. Eur J Clin Pharmacol 24, 837–839 (1983). https://doi.org/10.1007/BF00607097

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  • DOI: https://doi.org/10.1007/BF00607097

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