Summary
The absorption of a theophylline solution containing 80–120 mg doses delivered to different sites in the gastro-intestinal tract has been determined in 3 male volunteers using a remote controlled drug release system (HF-capsule). There was no difference between the stomach, ileum and the colon in the amount of theophylline absorbed (AUC). The T1/2abs of theophylline absorbed via the colon was prolonged when compared with that entering via the upper gastro-intestinal tract. The results provide a rational basis for the further development of theophylline formulations and are indispensable for planned development and to account for variation in the bioavailability of retarded release drug preparations.
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in technical collaboration with B. Hugemann, Frankfurt/Main
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Staib, A.H., Loew, D., Harder, S. et al. Measurement of theophylline absorption from different regions of the gastro-intestinal tract using a remote controlled durg delivery device. Eur J Clin Pharmacol 30, 691–697 (1986). https://doi.org/10.1007/BF00608217
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DOI: https://doi.org/10.1007/BF00608217