Summary
The pharmacokinetics of a single dose of phenazone was studied in six subjects while ambulant and during bed rest for 3 days. Elimination of the drug was followed for 12 h after oral and intravenous administration. The elimination rate constant and total body clearance were significantly increased during bed rest as compared to the ambulant period, but the differences were small. The apparent volume of distribution decreased significantly. No consistent change due to bed rest was found in the rate of absorption or bioavailability of the oral dose.
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References
Bevegård, S., Holmgren, A., Johnson, B.: The effect of body position on the circulation at rest and during exercise with special reference to the influence on the stoke volume. Acta physiol. scand.49, 279–298 (1960)
Brodie, B.B., Axelrod, J.: The fate of antipyrine in man. J. Pharmacol. exp. Ther.98, 97–101 (1950)
Culbertson, J.W., Wilkins, R.W., Ingelfinger, F.J., Bradley, S.E.: The effect of the upright posture upon hepatic blood flow in normotensive and hypertensive subjects. J. clin. Invest.30, 305–311 (1951)
Dettli, L., Spring, P.: Diurnal variations in the elimination rate of a sulphonamide in man. Helv. med. acta33, 291–306 (1966)
Elfström, J., Johansson, H., Lindgren, S.: Postoperative disappearance of phenazone from plasma in man. Europ. J. clin. Pharmacol.10, 63–68 (1976)
Gillette, J.R.: Factors affecting drug metabolism. Ann. N. Y. Acad. Sci.179, 43–66 (1971)
Greisen, G., Andreasen, P.B.: Two compartment analysis of plasma elimination of phenazone in normals and in patients with cirrhosis of the liver. Acta pharmacol. toxicol.38, 49–58 (1976)
Levy, G.: Effect of bedrest on distribution and elimination of drugs. J. Pharm. Sci.56, 928–929 (1967)
Lindgren, S., Collste, P., Norlander, B., Sjöqvist, F.: Gas chromatographic assessment of the reproducibility of phenazone plasma half-lives in young healthy volunteers. Europ. J. clin. Pharmacol.7, 381–385 (1974)
Miller, P.B., Johnson, R.L., Lamb, L.E.: Effects of four weeks of absolute bedrest on circulatory functions in man. Aerospace med.35, 1194–1200 (1964)
Schmidt, H., Roholt, K.: Penicillin serum concentrations in relation to exercise. Acta path. microbiol. scand.68, 396–400 (1966)
Selkurt, E.E.: The renal circulation. Handbook of Physiology Section 2, Circulation, vol 2, pp. 1457–1507. Baltimore: Williams and Wilkins 1963
Wilkinson, G.R., Shand, D.G.: A physiological approach to hepatic drug clearance. Clin. Pharmacol. Ther.18, 377–390 (1975)
Vogt, F.B., Johnson, P.C.: Plasma volume and extracellular fluid volume change associated with 10 days bed recumbency. Aerospace med.38, 21–25 (1967)
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Elfström, J., Lindgren, S. Influence of bed rest on the pharmacokinetics of phenazone. Eur J Clin Pharmacol 13, 379–383 (1978). https://doi.org/10.1007/BF00644612
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DOI: https://doi.org/10.1007/BF00644612