Summary
The localization of several peptidases in the human kidney was investigated histochemically. The membrane-bound peptidases, aminopeptidase A (APA), aminopeptidase M, γ-glutamyltransferase (γ-GT) and dipeptidylpeptidase IV, were mainly demonstrable in the brush border of the proximal tubule. In addition, APA was found in the glomeruli, while γ-GT was found in the basal labyrinth of the proximal tubule. The lysosomal peptidases, dipeptidylpeptidase I and cathepsin B, were most strongly concentrated in the different-sized lysosomes of the proximal tubule, but they were also found in the small lysosomes of the distal tubule. Dipeptidylpeptidase II showed only a weak reaction in lysosomes of the proximal tubule. It is concluded that, in comparison with other previously studied species, the human kidney has a well-developed equipment with membrane-bound and lysosomal peptidases.
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Supported by the Deutsche Forschungsgemeinschaft (SFB 105)
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Kugler, P., Wolf, G. & Scherberich, J. Histochemical demonstration of peptidases in the human kidney. Histochemistry 83, 337–341 (1985). https://doi.org/10.1007/BF00684380
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DOI: https://doi.org/10.1007/BF00684380