Abstract
Several important statistical aspects of pharmacokinetic analyses by digital computer are discussed. These include selection of appropriate equations, weighting of data, precision of parameter estimates, comparisons of parameters, analysis of weighted residuals, and criteria useful in the selection of particular models. Data obtained after administration of isoniazid and isonicotinuric acid to man are analyzed to illustrate the usefulness of the discussed methods.
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This work was supported in part by National Institutes of Health Training Grants GM 00728 and GM 16496, U.S. Public Health Service, Bethesda, Maryland.
Abstracted in part from a dissertation submitted by Harold G. Boxenbaum to the Graduate Division, University of California, San Francisco Medical Center, San Francisco, California, in partial fulfillment of the Doctor of Philosophy degree requirements.
Note: This manuscript was submitted to a Consulting Editor who served as the Journal editor during its review process.
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Boxenbaum, H.G., Riegelman, S. & Elashoff, R.M. Statistical estimations in pharmacokinetics. Journal of Pharmacokinetics and Biopharmaceutics 2, 123–148 (1974). https://doi.org/10.1007/BF01061504
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DOI: https://doi.org/10.1007/BF01061504