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Quantitative pooling of Michaelis-Menten equations in models with parallel metabolite formation paths

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Abstract

Pooling of Michaelis-Menten equations for models having parallel paths for formation of two or more metabolites is discussed. A theory which explains phenomena exhibited by pooled nonlinear pharmacokinetic systems and equations relating pooled Michaelis-Menten constants (V p ,K p )to microscopic constants (V i ,K i )are presented. The suitability of this type of pooling for use in pharmacokinetic modeling is also discussed. Use of pooling concepts in the design of clinical studies is demonstrated.

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Supported in part by Public Health Service Grant 5-P11-GM15559.

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Sedman, A.J., Wagner, J.G. Quantitative pooling of Michaelis-Menten equations in models with parallel metabolite formation paths. Journal of Pharmacokinetics and Biopharmaceutics 2, 149–160 (1974). https://doi.org/10.1007/BF01061505

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  • DOI: https://doi.org/10.1007/BF01061505

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