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Organization of the human serotonin transporter gene

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Summary

The gene encoding the human serotonin transporter (5-HTT) has been isolated and characterized. The human 5-HTT gene is composed of 14 exons spanning ∼ 31 kb. The sequence of all exons including adjacent intronic sequences and a tandem repeat DNA polymorphism (VNTR) has been determined and deposited in the EMBL/GenBank data base with the accession numbers X76753 to X76762. The characterization of 5-HTT gene will aid to advance molecular pharmacologic studies of 5-HT uptake regulation and facilitate investigations of its role in psychiatric disorders.

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Author notes

  1. K. -P. Lesch

    Present address: Clinical Neurochemistry, Department of Psychiatry, University of Würzburg, Federal Republic of Germany

Authors and Affiliations

  1. Clinical Neurochemistry, Department of Psychiatry, University of Würzburg, Federal Republic of Germany

    U. Balling, J. Gross & P. Riederer

  2. LCS, NIMH, NIH Clinical Center, Bethesda, MD, USA

    K. Strauss, B. L. Wolozin & D. L. Murphy

Authors
  1. K. -P. Lesch
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  2. U. Balling
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  3. J. Gross
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  4. K. Strauss
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  5. B. L. Wolozin
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  6. D. L. Murphy
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  7. P. Riederer
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Lesch, K.P., Balling, U., Gross, J. et al. Organization of the human serotonin transporter gene. J. Neural Transmission 95, 157–162 (1994). https://doi.org/10.1007/BF01276434

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  • DOI: https://doi.org/10.1007/BF01276434

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