Abstract
Quantitative ultrasound of the calcaneus and hip axis length are independent predictors of hip fracture and have a major genetic component. Polymorphisms of the vitamin D receptor gene (VDR) have been associated with variations in bone density in a number of studies. The aim of this study was to examine the role of VDR on other parameters associated with the risk of fracture. One hundred and eighty-nine pairs of healthy female dizygous twins were genotyped and had calcaneal ultrasound (broadband ultrasound attenuation and velocity of sound) and hip axis length measurements performed. Twin analysis using intraclass correlation coefficients and intrapair differences failed to find an association between the VDR polymorphisms and hip axis length or calcaneal ultrasound. Analysing the twins as a population, irrespective of twinning, also failed to find any association. The search for alternative genes influencing bone fragility should continue as a research priority.
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References
Pocock N, Eisman J, Hopper JL, Yeates M, Sambrook P, Eberl S. Genetic determinants of bone mass in adults. J Clin Invest 1987;80:706–10.
Dequeker J, Nijs J, Verstaeten A, Geusen P, Gevers G. Genetic determinants of bone mineral content at the spine and radius: a twin study. Bone 1987;8:207–9.
Morrison NA, Qi JI, Tokita A, Kelly PJ, Crofts L, Nguyen TV, et al. Prediction of bone density from vitamin D receptor alleles. Nature 1994;367:284–7.
Eisman JA. Vitamin D receptor gene alleles and osteoporosis: an affirmative view. J Bone Miner Res 1995;10:1289–93.
Faulkner KG, McClung MR, Coleman LJ, Kingston-Sandhal E. Quantitative ultrasound of the heel: correlation with densitometric measurements at different skeletal sites. Osteoporosis Int 1994;4:42–7.
Ross PD, Huang C, Davis JW, Imose K, Yates J, Vogel J, Wasnich RD. Predicting vertebral deformity using bone densitometry at various skeletal sites and calcaneus ultrasound. Bone 1995;16:325–32.
Hans D, Dargent P, Schott AM, Seber JL, Cormier C, Kotsci PO, et al. Ultrasound parameters predict hip fracture independently of hip bone density: the EPIDOS prospective study. J Bone Miner Res 1995;10(Suppl 1):S169.
Arden NK, Baker J, Hogg C, Baan K, Spector TD. The heritability of bone mineral density, ultrasound of the calcaneus and hip axis length: a study of postmenopausal twins. J Bone Miner Res 1996;11:530–34.
Faulkner KG, Cummings SR, Black D, Palermo L, Gluer CC, Genant HK. Simple measurement of femoral geometry predicts hip fracture: the study of osteoporotic fractures. J Bone Miner Res 1993;8:1211–7.
Hayes JG, Nguyen TV, Kelly PJ, Qi JI, Morrison NA, Pocock NA, et al. Vitamin D receptor alleles and femoral neck axis length. J Bone Miner Res 1995;10 (Suppl 1):S162.
Williams CJ, Christian JC, Norton JA Jr. TWINAN90: a FORTRAN programme for conducting ANOVA-based and likelihood based analyses of twin data. Comput Methods Programmes Biomed 1992;38:167–76.
Gluer CC, Wu CY, Jergas M, Goldstein SA, Genant HK. Three quantitative ultrasound parameters reflect bone structure. Calcif Tissue Int 1994;55;46–52.
Gluer CC, Cummings SR, Pressman A, Li J, Gluer K, Faulkner K, et al. Prediction of hip fractures from pelvic radiographs; the study of osteoporotic fractures. J Bone Miner Res 1994;9:671–7.
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Arden, N.K., Keen, R.W., Lanchbury, J.S. et al. Polymorphisms of the vitamin d receptor gene do not predict quantitative ultrasound of the calcaneus or hip axis length. Osteoporosis Int 6, 334–337 (1996). https://doi.org/10.1007/BF01623395
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DOI: https://doi.org/10.1007/BF01623395