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Absorption of erythromycin stearate and enteric-coated erythromycin base after a single oral dose immediately before breakfast

Absorption von Erythromycin-Stearat und Erythromycin-Base in magensaftresistenten Kapseln nach einer oralen Einzeldosis unmittelbar vor dem Frühstück

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Summary

To study the absorption of different preparations of erythromycin in the fasting state, 500 mg stearate (tablets) and 500 mg base (enteric-coated pellets) were given immediately before a standardised breakfast to 24 young, healthy volunteers in an open, random, cross-over trial. The serum peak concentration appeared earlier and was higher after intake of the stearate tablets than after intake of the base pellets; however, there was no difference in the area under the serum concentration vs. time curves (AUC) between the two preparations. The bioavailability of erythromycin stearate in tablet form and of erythromycin base in the form of enteric-coated pellets thus appears comparable when taken on an empty stomach.

Zusammenfassung

Um die Resorption verschiedener galenischer Zubereitungen von Erythromycin in nüchternem Zustand zu untersuchen, wurden in einer offenen, randomisierten Cross-over-Studie 500 mg des Stearats (Tabletten) und 500 mg der Base (magensaftresistente Kapseln) unmittelbar vor einem Standard-Frühstück an 24 junge, gesunde Freiwillige verabreicht. Die Serumspitzenkonzentration von Erythromycin trat nach Einnahme des Stearats früher ein und war höher als nach Einnahme der Base. Dagegen ergab sich kein Unterschied in der Fläche unter der Konzentrationskurve (AUC) zwischen den beiden Präparationen. Demgemäß erscheint die Bioverfügbarkeit von Erythromycin-Stearat in Tablettenform und Erythromycin-Base als magensaftresistente Kapseln vergleichbar, wenn sie auf leeren Magen eingenommen werden.

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Schreiner, A., Digranes, A. Absorption of erythromycin stearate and enteric-coated erythromycin base after a single oral dose immediately before breakfast. Infection 12, 345–348 (1984). https://doi.org/10.1007/BF01651150

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