Summary
To study the absorption of different preparations of erythromycin in the fasting state, 500 mg stearate (tablets) and 500 mg base (enteric-coated pellets) were given immediately before a standardised breakfast to 24 young, healthy volunteers in an open, random, cross-over trial. The serum peak concentration appeared earlier and was higher after intake of the stearate tablets than after intake of the base pellets; however, there was no difference in the area under the serum concentration vs. time curves (AUC) between the two preparations. The bioavailability of erythromycin stearate in tablet form and of erythromycin base in the form of enteric-coated pellets thus appears comparable when taken on an empty stomach.
Zusammenfassung
Um die Resorption verschiedener galenischer Zubereitungen von Erythromycin in nüchternem Zustand zu untersuchen, wurden in einer offenen, randomisierten Cross-over-Studie 500 mg des Stearats (Tabletten) und 500 mg der Base (magensaftresistente Kapseln) unmittelbar vor einem Standard-Frühstück an 24 junge, gesunde Freiwillige verabreicht. Die Serumspitzenkonzentration von Erythromycin trat nach Einnahme des Stearats früher ein und war höher als nach Einnahme der Base. Dagegen ergab sich kein Unterschied in der Fläche unter der Konzentrationskurve (AUC) zwischen den beiden Präparationen. Demgemäß erscheint die Bioverfügbarkeit von Erythromycin-Stearat in Tablettenform und Erythromycin-Base als magensaftresistente Kapseln vergleichbar, wenn sie auf leeren Magen eingenommen werden.
Similar content being viewed by others
Literature
Welling, P. G. Influence of food and diet on gastrointestinal drug absorption: a review. J. Pharmacokin. Biopharm. 5 (1977) 291–334.
Welling, P. G., Tse, F. L. S. The influence of food on the absorption of antimicrobial agents. J. Antimicrob. Chemother. 9 (1982) 7–27.
Chun, A. H. C., Seitz, J. A. Drug bioavailability information and its utility. J. Am. Pharm. Assoc. NS14 (1974) 407–414.
Chun, A. H. C., Seitz, J. A. Pharmacokinetics and biological availability of erythromycin. Infection 5 Suppl. (1977) S14-S22.
Hirsch, H. A., Finland, M. Effect of food on the absorption of erythromycin propionate, erythromycin stearate and triacetyloleandomycin. Am. J. Med. Sci. 237 (1959) 693–708.
Rutland, J., Berend, N., Marlin, G. E. The influence of food on the bioavailability of new formulations of erythromycin stearate and base. Br. J. Clin. Pharmacol. 8 (1979) 343–347.
Welling, P. G., Huand, H., Hewitt, P. F., Lyons, L. L. Bioavailability of erythromycin stearate: Influence of food and fluid volume. J. Pharm. Sci. 67 (1978) 764–766.
Welling, P. G., Elliott, R. L., Pitterle, M. E., Corrick-West, H. P., Lyons, L. L. Plasma levels following single and repeated doses of erythromycin estolate and erythromycin stearate. J. Pharm. Sci. 68 (1979) 150–155.
Clayton, D., Leslie, A. The bioavailability of erythromycin stearate versus enteric-coated erythromycin base when taken immediately before and after food. J. Int. Med. Res. 9 (1981) 470–477.
Malmborg, A.-S. Effect of food on absorption of erythromycin. A study of two derivatives, the stearate and the base. J. Antimicrob. Chemother. 5 (1979) 591–599.
Mather, L. E., Austin, K. L., Philpot, C. R., McDonald, P. J. Absorption and bioavailability of oral erythromycin. Br. J. Clin. Pharmacol. 12 (1981) 131–140.
Digranes, A., Josefsson, K., Schreiner, A. Influence of food on the absorption of erythromycin from enteric-coated pellets and stearate tablets. Curr. Ther. Res. 35 (1984) 313–320.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Schreiner, A., Digranes, A. Absorption of erythromycin stearate and enteric-coated erythromycin base after a single oral dose immediately before breakfast. Infection 12, 345–348 (1984). https://doi.org/10.1007/BF01651150
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01651150