Skip to main content
Log in

Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4

  • Short Communications
  • Published:
Experientia Aims and scope Submit manuscript

Summary

The African treeCombretum caffrum (Combretaceae) has been found to contain a powerful inhibitor of tubulin polymerization (IC502–3 μM), the growth of murine lymphocytic leukemia (L 1210 and P 388 with ED50≈0.003 μM and human colon cancer cell lines [(e.g. LoVo (ED50=0.005 μg/ml), HT29 (ED50 0.02 μg/ml, Colo 205 (ED50=0.07 μg/ml), DLD-1 (ED50=0.005 μg/ml) and HCT-15 (ED50=0.0009 μg/ml)] designated combretastatin A-4 (1c). The structure assigned by spectral techniques was confirmed by synthesis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Pettit, G. R., Cragg, G. M., Herald, D. L., Schmidt, J. M., and Lohavanijaya, P., Can. j. Chem.60 (1982) 1374.

    Article  CAS  Google Scholar 

  2. Pettit, G. R., Singh, S. B., Niven, M. L., and Hamel, E., J. natl Prod. (1988) in press.

  3. Pettit, G. R., Singh, S. B., Niven, M. L., Hamel, E., and Schmidt, J. M., J. natl Prod.50 (1987) 119.

    Article  CAS  Google Scholar 

  4. Pettit, G. R., and Singh, S. B., Can. J. Chem.65 (1987) 2390.

    Article  CAS  Google Scholar 

  5. Pettit, G. R., Singh, S. B., Niven. M. L., and Schmidt, J. M., Can. J. Chem. (1988) in press.

  6. Predicatble (ref. 4,5)1H-and13C-NMR, infrared and mass spectral data, as well as acceptable elemental analyses, were obtained for each new compound.

Download references

Author information

Authors and Affiliations

Authors

Additional information

For the preceding part (145) of the series Antineoplastic Agents refer to: H. Hennings, P. M. Blumberg, G. R. Pettit, C. L. Herald, R. Shores and S. H. Yuspa,Carcinogenesis, in press.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pettit, G.R., Singh, S.B., Hamel, E. et al. Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4. Experientia 45, 209–211 (1989). https://doi.org/10.1007/BF01954881

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01954881

Key words

Navigation