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Cytotoxicity and DNA topoisomerase inhibitory activity of constituents isolated from the fruits ofEvodia officinalis

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Abstract

Four alkaloids (1–4), three quinolone alkaloids (5–7), and three flavanoid glucosides (8–10) were isolated from the fruits ofEvodia officinalis Dode, and their structures were determined from chemical and spectral data. Compounds,3, 8, 9 and10 were isolated from this plant for the first time. Of these compounds,1–3 and5–7 exhibited moderate cytotoxicities against cultured human colon carcinoma (HT-29), human breast carcinoma (MCF-7), and human hepatoblastoma (HepG-2). Compound8 showed strong inhibitory effects on DNA topoisomerases I and II (70 and 96% inhibition at a concentration of 20 μM, respectively).

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Correspondence to Jong-Keun Son.

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Xu, ML., Moon, DC., Lee, CS. et al. Cytotoxicity and DNA topoisomerase inhibitory activity of constituents isolated from the fruits ofEvodia officinalis . Arch Pharm Res 29, 541–547 (2006). https://doi.org/10.1007/BF02969262

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  • DOI: https://doi.org/10.1007/BF02969262

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