Abstract
Objective
Fruit juices can significantly change the pharmacokinetics of several drugs. Our objective was to investigate the effect of orange juice on the pharmacokinetics of the beta-blocking agent atenolol.
Methods
In a randomized cross-over study with two phases and a washout of 2 weeks, ten healthy volunteers took either 200 ml orange juice or water thrice daily for 3 days and twice on the fourth day. On the morning of day 3, each subject ingested 50 mg atenolol with an additional amount of either 200 ml orange juice or water. The plasma concentrations of atenolol and the cumulative excretion of atenolol into urine were measured up to 33 h after its dosing. Systolic and diastolic blood pressures and heart rate were recorded in a sitting position before the intake of atenolol and 2, 4, 6, and 10 h after.
Results
Orange juice decreased the mean peak plasma concentration (Cmax) of atenolol by 49% (range 16–59%, P<0.01), and the mean area under the plasma atenolol concentration–time curve (AUC0-33 h) by 40% (range 25–55%, P<0.01). The time of the peak concentration (tmax) and the elimination half-life (t1/2) of atenolol remained unchanged by orange juice. The amount of atenolol excreted into urine was decreased by 38% (range 17–60%, P<0.01), but the renal clearance remained unaltered. The average heart rate was slightly higher during the orange juice+atenolol phase than during the water+atenolol phase.
Conclusions
Orange juice moderately interferes with the gastrointestinal absorption of atenolol. This food–drug interaction can be of clinical significance.
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Acknowledgements
We thank Mrs. Eija Mäkinen-Pulli, Mrs. Lisbet Partanen, and Mr. Jouko Laitila for technical assistance and determination of drug concentrations. This study complies with the current laws of Finland. This study was supported by grants from the Helsinki University Central Hospital Research Fund.
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Lilja, J.J., Raaska, K. & Neuvonen, P.J. Effects of orange juice on the pharmacokinetics of atenolol. Eur J Clin Pharmacol 61, 337–340 (2005). https://doi.org/10.1007/s00228-005-0930-9
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DOI: https://doi.org/10.1007/s00228-005-0930-9