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Intrahepatic distribution of human glutathione-dependent formaldehyde dehydrogenase

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Histochemistry and Cell Biology Aims and scope Submit manuscript

Abstract.

By means of a microelectrophoretic separation technique the different forms of alcohol dehydrogenase can be detected in microdissected liver tissue samples of the nanogram range. Alcohol dehydrogenase 3 (the glutathione-dependent formaldehyde dehydrogenase) was demonstrated to be zonally distributed in the human liver parenchyma. A periportal/perivenous gradient is evident in both sexes, however, the periportal/perivenous ratio is higher in males. The biological functions of this enzymatic form and the possible role of the periportal maximum are discussed.

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Authors and Affiliations

  1. Institute of Anatomy, University of Basel, Pestalozzistrasse 20, 4056 Basel, Switzerland, Switzerland

    Piotr I. Maly, Valérie Crotet, Mireille Toranelli & Dieter Sasse

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  1. Piotr I. Maly
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  2. Valérie Crotet
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  3. Mireille Toranelli
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  4. Dieter Sasse
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Maly, P.I., Crotet, V., Toranelli, M. et al. Intrahepatic distribution of human glutathione-dependent formaldehyde dehydrogenase. Histochem Cell Biol 116, 465–469 (2001). https://doi.org/10.1007/s00418-001-0337-3

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  • DOI: https://doi.org/10.1007/s00418-001-0337-3

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