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Sulfotransferase 1A1 (SULT1A1) polymorphism and susceptibility to primary brain tumors

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Abstract

Purpose

Sulfotransferase 1A1 is a member of sulfotransferase family that plays an important role in the biotransformation of numerous carcinogenic and mutagenic compounds through sulfation. The present study has investigated the association between SULT1A1 polymorphism and primary brain tumor incidence.

Methods

SULT1A1 genotypes were successfully detected using the PCR-RFLP assay in 60 primary brain tumor patients and 156 hospital-based healthy control individuals with no history of cancer or precancerous disorder.

Results

There was a significant difference in genotypes distribution (GG vs. GA + AA) between brain tumor patients (GG genotype frequency = 48.3%) and control population (GG genotype frequency = 65.4%; OR = 2.019, 95% CI = 1.103–3.695; P = 0.022). In order to determine the association between SULT1A1 polymorphism and specific types of brain tumors, the patients were classified according to the type of brain tumors they suffer from: glial and non-glial. Results of the statistical analyses of each group of patients in comparison with the control individuals showed a significant difference only between SULT1A1 polymorphism and non-glial brain tumors (OR = 2.615; 95% CI = 1.192–5.739; P = 0.014) but glial tumors (OR = 1.535; 95% CI = 0.688–3.425; P = 0.293). When non-glial tumors were classified as meningiomal and others (pituitary adenoma, craniopharyngioma, acoustic neuroma and hemangioblastoma), statistical analysis showed that this significance is only due to the meningiomal tumors (OR = 3.238; CI = 1.205–8.704; P = 0.015). We also estimated a reduced risk of brain tumor in non-smokers (OR = 1.700; CI = 0.800–3.615) in comparison to smokers (OR = 2.773; CI = 0.993–7.749), but this was not statistically significant.

Conclusion

Our findings have suggested that there was a significant association between brain tumor and SULT1A1*2 allele (A allele that is also known as His allele) and this allele is an important risk factor in the development of meningiomal brain tumors.

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Acknowledgments

This work was supported financially by the Research Council of Cumhuriyet University, Sivas, Turkey.

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Authors and Affiliations

  1. Department of Biology, Faculty of Science and Literature, Adnan Menderes University, 09100, Aydın, Turkey

    F. Bardakci

  2. Department of Molecular Biology and Genetics, Faculty of Science and Literature, Cumhuriyet University, 58140, Sivas, Turkey

    S. Arslan

  3. Department of Neurosurgery, Tepecik Hospital, Gaziler Street, Yenişehir, İzmir, Turkey

    S. Bardakci & A. O. Binatli

  4. Department of Biology, Faculty of Science and Literature, Cumhuriyet University, 58140, Sivas, Turkey

    M. Budak

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  1. F. Bardakci
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  2. S. Arslan
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Correspondence to F. Bardakci.

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Bardakci, F., Arslan, S., Bardakci, S. et al. Sulfotransferase 1A1 (SULT1A1) polymorphism and susceptibility to primary brain tumors. J Cancer Res Clin Oncol 134, 109–114 (2008). https://doi.org/10.1007/s00432-007-0256-3

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  • DOI: https://doi.org/10.1007/s00432-007-0256-3

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