Skip to main content

Advertisement

Log in

Neurotransmitter amino acids in cerebrospinal fluid of patients with Alzheimer's disease

  • Published:
Journal of Neural Transmission Aims and scope Submit manuscript

Summary.

We measured the CSF and plasma levels of glutamate, glutamine, aspartate (only in plasma), asparagine, glutamine, glycine and GABA in 37 patients with Alzheimer's disease and in 32 matched controls. We used an ion-exchange chromatography method. When compared to controls, AD patients had higher CSF glutamate and glycine levels, higher plasma levels of aspartate and glycine, and lower plasma levels of asparagine and GABA. When expressed relative to CSF proteins, CSF levels of glutamate and glycine remained higher, and CSF asparagine levels were lower in AD patients than in controls. The CSF levels of the amino acids measured were not correlated with the clinical features of AD with the exception of plasma GABA levels with duration of the disease. Our results might suggest a possible pathogenetic role of neurotransmitter amino acids in AD.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

Authors

Additional information

Accepted December 2, 1997; received August 30, 1997

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jiménez-Jiménez, F., Molina, J., Gómez, P. et al. Neurotransmitter amino acids in cerebrospinal fluid of patients with Alzheimer's disease. J Neural Transm 105, 269–277 (1998). https://doi.org/10.1007/s007020050056

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s007020050056

Navigation