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Response to the Comment on the Article “Physiologically Based Modeling of Pravastatin Transporter-Mediated Hepatobiliary Disposition and Drug-Drug Interactions”

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References

  1. Varma MV, Lai Y, Feng B, Litchfield J, Goosen TC, Bergman A. Physiologically based modeling of pravastatin transporter-mediated hepatobiliary disposition and drug-drug interactions. Pharm Res. 2012;29:2860–73.

    Article  PubMed  CAS  Google Scholar 

  2. Kimoto E, Yoshida K, Balogh LM, Bi YA, Maeda K, El-Kattan A et al. Characterization of Organic Anion Transporting Polypeptide (OATP) Expression and Its Functional Contribution to the Uptake of Substrates in Human Hepatocytes. Mol Pharm (2012).

  3. Li N, Singh P, Mandrell KM, Lai Y. Improved extrapolation of hepatobiliary clearance from in vitro sandwich cultured rat hepatocytes through absolute quantification of hepatobiliary transporters. Mol Pharm. 2010;7:630–41.

    Article  PubMed  CAS  Google Scholar 

  4. Jones HM, Barton HA, Lai Y, Bi YA, Kimoto E, Kempshall S, et al. Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data. Drug Metab Dispos. 2012;40:1007–17.

    Article  PubMed  CAS  Google Scholar 

  5. Kato M, Shitara Y, Sato H, Yoshisue K, Hirano M, Ikeda T, et al. The quantitative prediction of CYP-mediated drug interaction by physiologically based pharmacokinetic modeling. Pharm Res. 2008;25:1891–901.

    Article  PubMed  CAS  Google Scholar 

  6. Varma MV, Lai Y, Kimoto E, Goosen TC, El-Kattan AF, Kumar V. Mechanistic modeling to predict the transporter- and enzyme-mediated drug-drug interactions of repaglinide. Pharm Res. 2013. doi:10.1007/s11095-012-0956-5.

  7. Lee E, Ryan S, Birmingham B, Zalikowski J, March R, Ambrose H, et al. Rosuvastatin pharmacokinetics and pharmacogenetics in white and Asian subjects residing in the same environment. Clin Pharmacol Ther. 2005;78:330–41.

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Manthena V. S. Varma.

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Varma, M.V.S., Lai, Y., Feng, B. et al. Response to the Comment on the Article “Physiologically Based Modeling of Pravastatin Transporter-Mediated Hepatobiliary Disposition and Drug-Drug Interactions”. Pharm Res 30, 1469–1470 (2013). https://doi.org/10.1007/s11095-013-0987-6

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  • DOI: https://doi.org/10.1007/s11095-013-0987-6

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