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Antiobesity effects of Kaempferia parviflora in spontaneously obese type II diabetic mice

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Abstract

Kaempferia parviflora Wall. Ex Baker (KP) has been used as a folk medicine in Laos and Thailand to lower blood glucose levels, improve blood flow, and increase vitality. This study investigated the preventive effects of KP on obesity and its downstream symptoms (various metabolic disorders) using Tsumura, Suzuki, Obese Diabetes (TSOD) mice, a multifactorial genetic disease animal model in which metabolic diseases develop spontaneously, similar to metabolic syndrome in humans, and Tsumura, Suzuki, Non-Obesity (TSNO) mice as the corresponding control mice. When feed that was mixed with KP (1 or 3%) was given ad libitum to TSOD and TSNO mice for 8 weeks, body weight increase, visceral fat accumulation, lipid metabolism abnormalities, hyperinsulinemia, glucose intolerance, insulin resistance, hypertension, and peripheral neuropathy were suppressed in TSOD mice, but no marked differences were observed in TSNO mice. Because KP had preventive effects on metabolic diseases, including antiobesity effects, only in obese animals, we propose that KP will be extremely valuable as a medicine or component of food in alternative health care.

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Acknowledgments

This study was supported in part by the Matching Fund Subsidy for Private Universities of the Ministry of Education, Culture, Sports, Science and Technology (High Technology Research Center Project, 2004–2008).

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Authors and Affiliations

  1. Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan

    Tomoko Akase & Hiromi Sanada

  2. Research Institute of Pharmaceutical Sciences, Musashino University, 1-1-20 Shinmachi, Nishitokyo, Tokyo, 202-8585, Japan

    Tsutomu Shimada & Masaki Aburada

  3. Laboratory of Medicinal Resources, Department of Kampo Pharmacy, Yokohama College of Pharmacy, 601 Matano-cho, Totsuka, Yokohama, Kanagawa, 245-0066, Japan

    Susumu Terabayashi

  4. Department of Pharmacy, Ritsumeikan University, 1-1-1 Noji-higashi, Kusatsu, Shiga, 525-8577, Japan

    Yukinobu Ikeya

Authors
  1. Tomoko Akase
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  2. Tsutomu Shimada
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  3. Susumu Terabayashi
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  4. Yukinobu Ikeya
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  6. Masaki Aburada
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Corresponding author

Correspondence to Masaki Aburada.

Additional information

T. Akase and T. Shimada contributed equally to this work.

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Akase, T., Shimada, T., Terabayashi, S. et al. Antiobesity effects of Kaempferia parviflora in spontaneously obese type II diabetic mice. J Nat Med 65, 73–80 (2011). https://doi.org/10.1007/s11418-010-0461-2

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  • DOI: https://doi.org/10.1007/s11418-010-0461-2

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