Symposium on new aspects of antiarrhythmic therapyPharmacokinetics of antiarrhythmic drugs☆
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Cited by (28)
The inhibitory effects of nor-oleanane triterpenoid saponins from Stauntonia brachyanthera towards UDP-glucuronosyltransferases
2016, FitoterapiaCitation Excerpt :Whereas, it must be pointed out that the data obtained in vitro sometimes tend to underestimate the inhibition of drug glucuronidation in vivo, and the pharmacokinetic parameters used here to calculate concentrations are mean values of the parameters reported, but interindividual variability is large. Quinidine, for example, could competitively influence the AZT glucuronidation by inhibiting UGT2B7, with Ki value of 186 μM [28], the actual therapeutic plasma concentration range in vivo was 2–5 μg/mL, equivalent to 6–15 μM [29]. That is to say, the actual effects of the compounds might be more potent than these calculated here.
Effects of lidocaine and verapamil on defibrillation in humans
1991, Journal of ElectrocardiologyChronic ventricular arrhythmias: Which drug for which patient?
1988, The American Journal of CardiologyComputer-assisted individualized lidocaine dosage: Clinical evaluation and comparison with physician performance
1987, American Heart JournalDetermination of nicainoprol, a new antiarrhythmic agent, in human plasma and urine by high-performance liquid chromatography
1986, Journal of Chromatography B: Biomedical Sciences and Applications
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This work is supported in part by National Institutes of Health Grants 15431 and 20770, Bethesda, Maryland.
Copyright © 1978 Published by Elsevier Inc.