Influence of hemodialysis on acyclovir pharmacokinetics in patients with chronic renal failure
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Cited by (36)
Novel Insights to Enhance Therapeutics With Acyclovir in the Management of Herpes Simplex Encephalitis
2021, Journal of Pharmaceutical SciencesCitation Excerpt :Data reported suggested that serum creatinine <0.7 mg L−1 or 60 μmol L−1 characterize the normal renal function in term newborn.7,18,19 The single-dose kinetics and safety of acyclovir in humans were evaluated by phase I clinical trials after administration by constant-rate IV infusion to subjects with advanced malignancies4,20–25 or with renal dysfunction.12,26,27 Data are fitted to a 2-compartment open kinetic model with zero-order input (slow and constant drug administration).
Pharmacokinetic-Pharmacodynamic Basis of Optimal Antibiotic Therapy
2018, Principles and Practice of Pediatric Infectious DiseasesAntiviral Agents
2018, Principles and Practice of Pediatric Infectious DiseasesThe Use of Antiviral Drugs During the Neonatal Period
2012, Clinics in PerinatologyCitation Excerpt :Elimination is prolonged in patients with renal dysfunction; the half-life is approximately 20 hours in persons with end-stage renal disease, necessitating dose modifications for those with creatinine clearance less than 50 mL/min/1.73 m2.19 Acyclovir is effectively removed by hemodialysis but not by continuous ambulatory peritoneal dialysis.20,21 Acyclovir generally is a safe drug.
Pharmacokinetic-Pharmacodynamic Basis of Optimal Antibiotic Therapy
2012, Principles and Practice of Pediatric Infectious Diseases, Fourth EditionAntiviral Agents
2012, Principles and Practice of Pediatric Infectious Diseases, Fourth Edition
- 1
From the Wellcome Research Laboratories, Burroughs Wellcome Co., Research Triangle Park, North Carolina.
- 2
From the Division of Clinical Pharmacology, The Johns Hopkins University School of Medicine, Baltimore, Maryland.