Metabolic fate of radioactive acyclovir in humans
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Cited by (34)
Therapeutic monitoring of serum concentrations of acyclovir and its metabolite 9-(carboxymethoxymethyl) guanine in routine clinical practice
2022, Biomedicine and PharmacotherapyCitation Excerpt :Aldehyde oxidase metabolizes ACV into 8- hydroxy-9-(2- hydroxyethoxymethyl) guanine (8-OH-ACV). In patients without renal failure, 62.1–91.0% of intravenous ACV is excreted through the urine as the unchanged, 8.5–14.1% as CMMG, and less than 0.2% as 8-OH-ACV metabolite [27–30]. The main route of ACV elimination is renal excretion, which involves glomerular filtration and active tubular secretion.
Predicting Pharmacokinetics of Multisource Acyclovir Oral Products Through Physiologically Based Biopharmaceutics Modeling
2022, Journal of Pharmaceutical SciencesNovel Insights to Enhance Therapeutics With Acyclovir in the Management of Herpes Simplex Encephalitis
2021, Journal of Pharmaceutical SciencesCitation Excerpt :In the controlled studies, mainly in open-label studies, the safety of IV acyclovir administration was suggested because many trials did not report adverse effects. The percentage of none or not reported adverse effects was 65% and 36% in open-label trials4,12,20–23,26,27,29,34,38,54,58,64 and double blind trials,42,55,56,61,63 respectively. In open-label studies, the main adverse effects reported were nephrotoxicity in three studies1,19,24 and local reaction at the injection site, also in three studies.37,53,57
Antivirals against Herpes Viruses
2014, Mandell, Douglas, and Bennett's Principles and Practice of Infectious DiseasesAcyclovir-induced nephrotoxicity: The role of the acyclovir aldehyde metabolite
2011, Translational ResearchCitation Excerpt :Finally, it can be speculated that the small effect may have been caused by the possibility that the parent drug acyclovir may also play a role in the direct toxicity. As elaborated previously, acyclovir undergoes minimal metabolism via the ADH and ALDH pathway19; therefore, it is possible that the ADH enzyme has a weak affinity for the parent drug. If this is the case, then in addition to its aldehyde metabolite, the parent drug may also play an active role and may even be the more predominant offending nephrotoxic.
- 1
From the Wellcome Research Laboratories, Research Triangle Park, North Carolina.
- 2
From the University of California, San Diego, California.
- 3
From the Johns Hopkins University, Baltimore, Maryland.