Report on therapyQuinine pharmacokinetics and toxicity in cerebral and uncomplicated falciparum malaria☆
References (25)
The treatment of severe falciparum malaria
Trans R Soc Trop Med Hyg
(1977)- et al.
Concept of a volume of distribution and possible errors in evaluation of this parameter
J Pharm Sci
(1968) - et al.
Quinine therapy and peritoneal dialysis in acute renal failure complicating malarial haemoglobinuria
Lancet
(1968) - et al.
Pathology of malaria
Quinine by continuous intravenous drip in the treatment of acute falciparum malaria
Trans R Soc Trop Med Hyg
(1948)The treatment of malaria
Br Med J
(1976)- et al.
Quinine dosage and serum levels in falciparum malaria
Annu Rep SEATO Med Res Labs
(1975) - et al.
Quantitative determination of quinidine in plasma
Scand J Clin Lab Invest
(1963) - et al.
Principles of drug action
- et al.
Cerebral malaria
JAMA
(1967)
Dexamethasone proves deleterious in cerebral malaria: double blind trial in 100 patients
N Engl J Med
Quinine disposition during malaria and during induced fever
Clin Pharmacol Ther
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2016, TherapieCitation Excerpt :The explanation lies in the pharmacokinetic characteristics of quinine. This drug is mainly eliminated by the liver, through microsomal enzyme cytochrome CYP450 3A4, with the hepatic clearance representing more than 80% of the total clearance [7,8]. Its low extraction coefficient (EH < 0.3) leads to a hepatic clearance that can be expressed as ClH = Clint χ ƒu where Clint is the intrinsic clearance corresponding to the metabolic capacities of hepatocytes, and ƒu the unbound plasma fraction.
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Supported by the Wellcome Trust of Great Britain as a part of the Wellcome-Mahidol University, Oxford Tropical Medicine Research Programme.
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From the Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, and the Tropical Medicine Unit, Nuffield Department of Clinical Medicine, University of Oxford, England.