Kinetic characterization of branched chain ketoacid dehydrogenase☆
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Cited by (17)
Muscle Physiology in Healthy Men and Women and Those with Metabolic Myopathies
2009, Physical Medicine and Rehabilitation Clinics of North AmericaCitation Excerpt :During endurance exercise there is an increase in leucine oxidation,89–92 contributing approximately 2% to 3% of total substrate oxidation during the exercise bout.92 Leucine is oxidized by branched-chain 2-oxoacid dehydrogenase (BCOAD) within the mitochondria (see Fig. 1).93 BCOAD is the rate-limiting enzyme in branched-chain amino acid (leucine, isoleucine, valine) oxidation and is activated upon dephosphorylation by a specific phosphatase and inactivated by BCOAD kinase.94
Muscle Physiology in Healthy Men and Women and Those with Metabolic Myopathies
2008, Neurologic ClinicsCitation Excerpt :During endurance exercise there is an increase in leucine oxidation [89–92], contributing approximately 2% to 3% of total substrate oxidation during the exercise bout [92]. Leucine is oxidized by branched-chain 2-oxoacid dehydrogenase (BCOAD) within the mitochondria (see Fig. 1) [93]. BCOAD is the rate-limiting enzyme in branched-chain amino acid (leucine, isoleucine, valine) oxidation and is activated upon dephosphorylation by a specific phosphatase and inactivated by BCOAD kinase [94].
Protein requirements for endurance athletes
2004, NutritionControl of mitochondrial β-oxidation flux
2002, Progress in Lipid ResearchEthanol and oleate inhibition of α-ketoisovalerate and 3-hydroxyisobutyrate metabolism by isolated hepatocytes
1992, Archives of Biochemistry and BiophysicsBranched-chain Amino Acids: Catabolism in Skeletal Muscle and Implications for Muscle and Whole-body Metabolism
2021, Frontiers in Physiology
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This work was supported by grants from the National Institutes of Health HL07098 (to B.B.) and GM32654 and GM37217 (to R.O.).
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